The Proliferation of Neointimal Smooth Muscle Cells Cultured from Rabbit Aortic Explants 15 Weeks After De-endothelialization by a Balloon Catheter

Overview

Journal Int J Exp Pathol

Publisher Wiley

Specialty Pathology

Date 1994 Jun 1

PMID 8086314

Citations 1

Authors

Z Li

M Z Alavi

S Moore

Affiliations

Soon will be listed here.

Abstract

Endothelial denudation of rabbit aorta induces smooth muscle cell (SMC) migration and proliferation, resulting in a thickened neointima, showing features in common with atherosclerotic lesions. The SMC proliferation has been reported as a transient healing process, which regresses when the neointima is covered by regenerated endothelium. In this study, we examined the cellular proliferation of neointimal SMC, derived from denuded and from re-endothelialized areas of aortic explants. The results show that the neointimal SMC retain a higher rate of proliferation, even 15 weeks after a single endothelial injury by a balloon catheter. Neointimal SMC release more PDGF-AB and TGF-beta 1, which may play a mitogenic role for SMC proliferation. The data demonstrating that injury-induced stimulation of neointimal SMC proliferation is a persistent process, emphasize the importance of injury mechanisms of atherogenesis.

Citing Articles

Antiproliferative and c-myc mRNA suppressive effect of tranilast on newborn human vascular smooth muscle cells in culture.

Miyazawa K, Hamano S, UJIIE A Br J Pharmacol. 1996; 118(4):915-22.

PMID: 8799562 PMC: 1909533. DOI: 10.1111/j.1476-5381.1996.tb15486.x.

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