Borna Disease Virus: Immunoelectron Microscopic Characterization of Cell-free Virus and Further Information About the Genome

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1994 Oct 1

PMID 8084008

Citations 10

Authors

W Zimmermann

H Breter

M Rudolph

H Ludwig

Affiliations

Soon will be listed here.

Abstract

The etiological agent of Borna disease, a persistent virus infection of the central nervous system with differently expressed symptomatology, was morphologically unknown. Here we provide the first convincing data on its phenotypic architecture. Salt-released virus comprising the biological parameters of Koch's postulates has an unsegmented single-stranded RNA. A dense band (1.22 g/cm3) in CsCl contains 90-nm particles which appear to be enveloped and a fraction of 50- to 60-nm particles. Labeling of the virions with neutralizing antisera and colloidal gold conjugates indicates that the 90-nm particles most likely represent the causative agent.

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References

Richt J, Vande Woude S, Zink M, Narayan O, Clements J . Analysis of Borna disease virus-specific RNAs in infected cells and tissues. J Gen Virol. 1991; 72 ( Pt 9):2251-5. DOI: 10.1099/0022-1317-72-9-2251. View

Gosztonyi G, Ludwig H . Borna disease of horses. An immunohistological and virological study of naturally infected animals. Acta Neuropathol. 1984; 64(3):213-21. DOI: 10.1007/BF00688111. View

Pauli G, Ludwig H . Increase of virus yields and releases of Borna disease virus from persistently infected cells. Virus Res. 1985; 2(1):29-33. DOI: 10.1016/0168-1702(85)90057-7. View

Ludwig H, Bode L, Gosztonyi G . Borna disease: a persistent virus infection of the central nervous system. Prog Med Virol. 1988; 35:107-51. View

Lipkin W, Travis G, Carbone K, Wilson M . Isolation and characterization of Borna disease agent cDNA clones. Proc Natl Acad Sci U S A. 1990; 87(11):4184-8. PMC: 54072. DOI: 10.1073/pnas.87.11.4184. View

de la Torre J, Carbone K, Lipkin W . Molecular characterization of the Borna disease agent. Virology. 1990; 179(2):853-6. DOI: 10.1016/0042-6822(90)90154-j. View

Vandewoude S, Richt J, Zink M, Rott R, Narayan O, Clements J . A borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases. Science. 1990; 250(4985):1278-81. DOI: 10.1126/science.2244211. View

Briese T, de la Torre J, Lewis A, Ludwig H, Lipkin W . Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells. Proc Natl Acad Sci U S A. 1992; 89(23):11486-9. PMC: 50576. DOI: 10.1073/pnas.89.23.11486. View

Gosztonyi G, Dietzschold B, Kao M, Rupprecht C, Ludwig H, KOPROWSKI H . Rabies and borna disease. A comparative pathogenetic study of two neurovirulent agents. Lab Invest. 1993; 68(3):285-95. View

10.

Pyper J, Richt J, Brown L, Rott R, Narayan O, Clements J . Genomic organization of the structural proteins of borna disease virus revealed by a cDNA clone encoding the 38-kDa protein. Virology. 1993; 195(1):229-38. DOI: 10.1006/viro.1993.1364. View

11.

Ludwig H, Furuya K, Bode L, Klein N, Durrwald R, Lee D . Biology and neurobiology of Borna disease viruses (BDV), defined by antibodies, neutralizability and their pathogenic potential. Arch Virol Suppl. 1993; 7:111-33. DOI: 10.1007/978-3-7091-9300-6_10. View

12.

Malkinson M, Weisman Y, Ashash E, Bode L, Ludwig H . Borna disease in ostriches. Vet Rec. 1993; 133(12):304. DOI: 10.1136/vr.133.12.304-b. View

13.

Sasaki S, Ludwig H . In borna disease virus infected rabbit neurons 100 nm particle structures accumulate at areas of Joest-Degen inclusion bodies. Zentralbl Veterinarmed B. 1993; 40(4):291-7. DOI: 10.1111/j.1439-0450.1993.tb00141.x. View

14.

Lundgren A, Czech G, Bode L, Ludwig H . Natural Borna disease in domestic animals others than horses and sheep. Zentralbl Veterinarmed B. 1993; 40(4):298-303. DOI: 10.1111/j.1439-0450.1993.tb00142.x. View

15.

Schneider P, Briese T, Zimmermann W, Ludwig H, Lipkin W . Sequence conservation in field and experimental isolates of Borna disease virus. J Virol. 1994; 68(1):63-8. PMC: 236264. DOI: 10.1128/JVI.68.1.63-68.1994. View

16.

Bode L, Steinbach F, Ludwig H . A novel marker for Borna disease virus infection. Lancet. 1994; 343(8892):297-8. DOI: 10.1016/s0140-6736(94)91147-9. View

17.

Cubitt B, de la Torre J . Borna disease virus (BDV), a nonsegmented RNA virus, replicates in the nuclei of infected cells where infectious BDV ribonucleoproteins are present. J Virol. 1994; 68(3):1371-81. PMC: 236591. DOI: 10.1128/JVI.68.3.1371-1381.1994. View

18.

Cubitt B, Oldstone C, de la Torre J . Sequence and genome organization of Borna disease virus. J Virol. 1994; 68(3):1382-96. PMC: 236592. DOI: 10.1128/JVI.68.3.1382-1396.1994. View

19.

Briese T, Schneemann A, Lewis A, Park Y, Kim S, Ludwig H . Genomic organization of Borna disease virus. Proc Natl Acad Sci U S A. 1994; 91(10):4362-6. PMC: 43785. DOI: 10.1073/pnas.91.10.4362. View

20.

Bestetti G . [Microscopic and ultrastructural studies on Joest-Degen inclusion bodies in spontaneous Borna disease of the horse]. Schweiz Arch Tierheilkd. 1976; 118(11):493-8. View