Overexpression of the SNQ3/YAP1 Gene Confers Hyper-resistance to Nitrosoguanidine in Saccharomyces Cerevisiae Via a Glutathione-independent Mechanism

Overview

Journal Curr Genet

Specialty Genetics

Date 1994 May 1

PMID 8082194

Citations 3

Authors

M Grey

M Brendel

Affiliations

Soon will be listed here.

Abstract

The MNNG hyper-resistance of yeast transformants containing multiple copies of the SNQ3/YAP1 yeast gene is not caused by lowered MNNG activation due to depleted pools of glutathione. On the contrary, the SNQ3/YAP1-encoded protein stimulates production of GSH, apparently by promoter activation due to the AP-1 recognition element. Expression of at least one further gene, encoding a protein with a strong detoxifying activity, must also be stimulated to explain the MNNG hyper-resistance phenotype.

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