Microcompartmentation of Energy Metabolism at the Outer Mitochondrial Membrane: Role in Diabetes Mellitus and Other Diseases

Overview

Journal J Bioenerg Biomembr

Publisher Springer

Specialties Biochemistry
Biology
Endocrinology

Date 1994 Jun 1

PMID 8077185

Citations 13

Authors

E R McCabe

Affiliations

Soon will be listed here.

Abstract

Complexes made up of the kinases, hexokinase and glycerol kinase, together with the outer mitochondrial membrane voltage-dependent anion channel (VDAC) protein, porin, and the inner mitochondrial membrane protein, the adenine nucleotide translocator, are involved in tumorigenesis, diabetes mellitus, and central nervous system function. Identification of these two mitochondrial membrane proteins, along with an 18 kD protein, as components of the peripheral benzodiazepine receptor, provides independent confirmation of the interaction of porin and the adenine nucleotide translocator to form functional contact sites between the inner and outer mitochondrial membranes. We suggest that these are dynamic structures, with channel conductances altered by the presence of ATP, and that ligand-mediated conformational changes in the porin-adenine nucleotide translocator complexes may be a general mechanism in signal transduction.

Citing Articles

Joint-based description of protein structure: its application to the geometric characterization of membrane proteins.

Thangappan J, Wu S, Lee S Sci Rep. 2017; 7(1):1056.

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Voltage-dependent anion channel (VDAC) is involved in apoptosis of cell lines carrying the mitochondrial DNA mutation.

Yuqi L, Lei G, Yang L, Zongbin L, Hua X, Lin W BMC Med Genet. 2009; 10:114.

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A study on the two binding sites of hexokinase on brain mitochondria.

Golestani A, Ramshini H, Nemat-Gorgani M BMC Biochem. 2007; 8:20.

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Comparative proteome analysis of breast cancer and normal breast.

Luo Y, Zhang J, Liu Y, Shaw A, Wang X, Wu S Mol Biotechnol. 2005; 29(3):233-44.

PMID: 15767701 DOI: 10.1385/MB:29:3:233.

Involvement of porin N,N-dicyclohexylcarbodiimide-reactive domain in hexokinase binding to the outer mitochondrial membrane.

Al Jamal J Protein J. 2005; 24(1):1-8.

PMID: 15756812 DOI: 10.1007/s10930-004-0600-2.

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