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Relationship Between Superoxide Dismutase and Melanin in a Pathogenic Fungus

Overview
Journal Infect Immun
Publisher American Society for Microbiology
Specialty Allergy & Immunology
Date 1994 Sep 1
PMID 8063430
Citations 26
Authors
E S Jacobson
N D Jenkins
J M Todd
Affiliations
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Abstract

Since melanin is considered a virulence factor in Cryptococcus neoformans, its suppression at 37 degrees C has been perplexing. We now show an opposite thermal regulation of superoxide dismutase (SOD), consistent with a compensatory mechanism. Moreover, we demonstrate normal SOD and catalase levels in albino, oxygen-sensitive mutants. These results suggest that melanin is an antioxidant factor comparable in importance to SOD.

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