Integrated Human Genome-wide Maps Constructed Using the CEPH Reference Panel

Overview

Journal Nat Genet

Specialty Genetics

Date 1994 Apr 1

PMID 8054980

Citations 45

Authors

K H Buetow

J L Weber

S Ludwigsen

G M Duyk

V C Sheffield

Z Wang

J C Murray

Affiliations

Soon will be listed here.

Abstract

High resolution linkage maps have proven to be invaluable tools in genetic investigations. We have assembled a collection of genetic maps constructed from primary data collected from investigators performing genotyping using the Centre Etude Polymorphism Humain (CEPH) reference pedigree panel. These maps were constructed using a rigorous, semi-automated map construction algorithm that evaluates the integrity of the maps during construction. Two classes of maps were produced: a high confidence "skeletal" set composed of 544 PCR based markers, and a more highly annotated "framework" set containing maps of 1,123 markers. Genetic map locations within the framework maps are provided for an additional 1,758 loci without statistically unique interval assignments.

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