[Effect of Defensin on Platelet Functional Activity]

Overview

Journal Biull Eksp Biol Med

Specialties Biology
General Medicine

Date 1993 Jan 1

PMID 8054565

Citations 1

Authors

I P Ashmarin

S B Tkachenko

I A Rudko

E A Korneva

V N Kokriakov

A A Kubatiev

Affiliations

Soon will be listed here.

Abstract

The effects of human neutrophil peptide defensin were studied on human platelet function. Defensin (0.1-40 micrograms/mL) did not promote platelet aggregation. Defensin decreased platelet aggregation responses to ADF, collagen or thrombin. Defensin significantly lessened ATP level, released during platelet aggregation, and malondialdehyde production, induced by thrombin and collagen. These data reveal that defensins involve in cell-cell interaction between platelets and neutrophils counteracting agonist-induced platelet activation.

Citing Articles

Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation.

Kraemer B, Campbell R, Schwertz H, Cody M, Franks Z, Tolley N PLoS Pathog. 2011; 7(11):e1002355.

PMID: 22102811 PMC: 3213094. DOI: 10.1371/journal.ppat.1002355.

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