Prediction of an RRNA Methyltransferase Domain in Human Tumor-specific Nucleolar Protein P120

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1994 Jul 11

PMID 8041608

Citations 11

Authors

E V Koonin

Affiliations

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Abstract

Using computer methods for identification of amino acid motifs in sequence databases and multiple alignment, it is shown that human proliferation-associated nucleolar protein P120 contains a putative methyltransferase domain that is conserved in a group of bacterial proteins. It is hypothesized that P120 and the related prokaryotic proteins are rRNA methylases required for division of all types of cells.

Citing Articles

Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120.

Bourgeois G, Ney M, Gaspar I, Aigueperse C, Schaefer M, Kellner S PLoS One. 2015; 10(7):e0133321.

PMID: 26196125 PMC: 4510066. DOI: 10.1371/journal.pone.0133321.

5-methylcytosine in RNA: detection, enzymatic formation and biological functions.

Motorin Y, Lyko F, Helm M Nucleic Acids Res. 2009; 38(5):1415-30.

PMID: 20007150 PMC: 2836557. DOI: 10.1093/nar/gkp1117.

Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae.

Hong B, Wu K, Brockenbrough J, Wu P, Aris J Nucleic Acids Res. 2001; 29(14):2927-37.

PMID: 11452018 PMC: 55797. DOI: 10.1093/nar/29.14.2927.

Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae.

Kressler D, Linder P, de la Cruz J Mol Cell Biol. 1999; 19(12):7897-912.

PMID: 10567516 PMC: 84875. DOI: 10.1128/MCB.19.12.7897.

Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences.

Reid R, Greene P, Santi D Nucleic Acids Res. 1999; 27(15):3138-45.

PMID: 10454610 PMC: 148540. DOI: 10.1093/nar/27.15.3138.

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