Uremia in the Rat Affects Gastric Cell Growth and Differentiation

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1994 Jul 1

PMID 8026257

Citations 1

Authors

E Quintero

G Ohning

P H Guth

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to determine if hypertrophy of different tissues seen in uremic rats included gastrointestinal hypertrophy and an increase in parietal cell mass that might explain the increased acid secretion we previously reported. Chronic renal failure was induced by subtotal nephrectomy. Despite a lower total body weight, uremic rats had a significantly greater stomach weight (33%), corpus area (13%), corpus mucosal height (19%), and parietal (32%) and enterochromaffin-like (ECL, 54%) cell density, but a 16% decrease in mucous neck cell region height. These findings suggest that uremia leads to gastric stem cell stimulation with differentiation favoring parietal and ECL cells over mucous cells. In addition, in uremic rats there was an increase in height of the duodenal mucosa, but not of the ileal or transverse colon mucosa. In conclusion, the present study shows that uremia in the rat promotes hypertrophy of the stomach with cell differentiation favoring parietal cells over mucus cells. The increase in parietal cell mass may explain the increased acid secretion in these rats.

Citing Articles

Gastric emptying of solids but not liquids is decreased in rats with chronic renal failure.

Raybould H, Plourde V, Zittel T, Bover J, Quintero E Dig Dis Sci. 1994; 39(11):2301-5.

PMID: 7956595 DOI: 10.1007/BF02087642.

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