Reproductive and Developmental Toxicity of the Components of Gasoline

Overview

Journal Environ Health Perspect

Date 1993 Dec 1

PMID 8020438

Citations 1

Authors

R G Skalko

Affiliations

Soon will be listed here.

Abstract

The reproductive, developmental, and postnatal toxicity of 14 select chemicals and mixtures that are components of gasoline has been reviewed. The majority of experimental analyses have been performed as either variations of the accepted segment 2 protocol or as traditional teratology studies. Specific deficiencies in the present database have been identified and are most obvious in the evaluation of reproductive and postnatal effects. It is recommended that future studies address the continuing need for assessment in multiple species and over a range of dosages with specific emphasis on the impact of route of administration on the results obtained.

Citing Articles

Biomarkers of leukemia risk: benzene as a model.

Smith M, Zhang L Environ Health Perspect. 1998; 106 Suppl 4:937-46.

PMID: 9703476 PMC: 1533331. DOI: 10.1289/ehp.98106s4937.

References

Kronick J . Teratogenic effects of ethyl alcohol administered to pregnant mice. Am J Obstet Gynecol. 1976; 124(7):676-80. DOI: 10.1016/s0002-9378(16)33334-8. View

Nau H . Species differences in pharmacokinetics and drug teratogenesis. Environ Health Perspect. 1986; 70:113-29. PMC: 1474298. DOI: 10.1289/ehp.8670113. View

Hudak A, UNGVARY G . Embryotoxic effects of benzene and its methyl derivatives: toluene, xylene. Toxicology. 1978; 11(1):55-63. DOI: 10.1016/s0300-483x(78)90439-0. View

Green J, Leong B, Laskin S . Inhaled benzene fetotoxicity in rats. Toxicol Appl Pharmacol. 1978; 46(1):9-18. DOI: 10.1016/0041-008x(78)90132-1. View

Abel E, Dintcheff B . Effects of prenatal alcohol exposure on growth and development in rats. J Pharmacol Exp Ther. 1978; 207(3):916-21. View

Schwetz B, Smith F, STAPLES R . Teratogenic potential of ethanol in mice, rats and rabbits. Teratology. 1978; 18(3):385-92. DOI: 10.1002/tera.1420180313. View

Boggan W, Randall C, DeBeukelaer M, Smith R . Renal anomalies in mice prenatally exposed to ethanol. Res Commun Chem Pathol Pharmacol. 1979; 23(1):127-42. View

Randall C, Taylor W . Prenatal ethanol exposure in mice: teratogenic effects. Teratology. 1979; 19(3):305-11. DOI: 10.1002/tera.1420190305. View

Klassen R, PERSAUD T . Influence of alcohol on the reproductive system of the male rat. Int J Fertil. 1978; 23(3):176-84. View

10.

Murray F, John J, Rampy L, Kuna R, Schwetz B . Embryotoxicity of inhaled benzene in mice and rabbits. Am Ind Hyg Assoc J. 1979; 40(11):993-8. DOI: 10.1080/15298667991430604. View

11.

Streissguth A, Martin J, Smith D . Teratogenic effects of alcohol in humans and laboratory animals. Science. 1980; 209(4454):353-61. DOI: 10.1126/science.6992275. View

12.

Tatrai E, UNGVARY G, Hudak A, Rodics K, Lorincz M, Barcza G . Concentration dependence of the embryotoxic effects of benzene inhalation in CFY rats. J Hyg Epidemiol Microbiol Immunol. 1980; 24(3):363-71. View

13.

Marks T, Worthy W, STAPLES R . Influence of formaldehyde and Sonacide (potentiated acid glutaraldehyde) on embryo and fetal development in mice. Teratology. 1980; 22(1):51-8. DOI: 10.1002/tera.1420220108. View

14.

Wiener S, Shoemaker W, Koda L, Bloom F . Interaction of ethanol and nutrition during gestation: influence on maternal and offspring development in the rat. J Pharmacol Exp Ther. 1981; 216(3):572-9. View

15.

Biles R, Schroeder R, Holdsworth C . Methyl tertiary butyl ether inhalation in rats: a single generation reproduction study. Toxicol Ind Health. 1987; 3(4):519-34. DOI: 10.1177/074823378700300406. View

16.

Middaugh L, Randall C, Favara J . Prenatal ethanol exposure in C57 mice: effects on pregnancy and offspring development. Neurotoxicol Teratol. 1988; 10(2):175-80. DOI: 10.1016/0892-0362(88)90082-7. View

17.

Skalko R . Pharmacological concepts and developmental toxicology. Ann N Y Acad Sci. 1989; 562:21-30. DOI: 10.1111/j.1749-6632.1989.tb21004.x. View

18.

Saillenfait A, Bonnet P, De Ceaurriz J . The effects of maternally inhaled formaldehyde on embryonal and foetal development in rats. Food Chem Toxicol. 1989; 27(8):545-8. DOI: 10.1016/0278-6915(89)90051-3. View

19.

Slomianka L, Edelfors S, RAVN-JONSEN A, Rungby J, Danscher G, West M . The effect of low-level toluene exposure on the developing hippocampal region of the rat: histological evidence and volumetric findings. Toxicology. 1990; 62(2):189-202. DOI: 10.1016/0300-483x(90)90109-t. View

20.

da Silva V, Malheiros L, Paumgartten F, Riul T, Golovattei M . Developmental toxicity of in utero exposure to toluene on malnourished and well nourished rats. Toxicology. 1990; 64(2):155-68. DOI: 10.1016/0300-483x(90)90132-z. View