Kinetics Versus Thermodynamics in Protein Folding

Overview

Journal Biochemistry

Specialty Biochemistry

Date 1994 Jun 21

PMID 8011615

Citations 65

Authors

D Baker

D A Agard

Affiliations

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Abstract

Until quite recently it has been generally believed that the observed tertiary structure of a protein is controlled by thermodynamic and not kinetic processes. In this essay we review several recent results which call into question the universality of the thermodynamic hypothesis and discuss their implications for the understanding of protein folding.

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