Pyrroindomycins, Novel Antibiotics Produced by Streptomyces Rugosporus Sp. LL-42D005. I. Isolation and Structure Determination

Overview

Journal J Antibiot (Tokyo)

Specialties Infectious Diseases
Pharmacology

Date 1994 Nov 1

PMID 8002387

Citations 13

Authors

W Ding

D R Williams

P Northcote

M M Siegel

R Tsao

J Ashcroft

G O Morton

M Alluri

D Abbanat

W M Maiese

Affiliations

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Abstract

Pyrroindomycins A and B were isolated from fermentations of culture LL-42D005, a strain of Streptomyces rugosporus. Pyrroindomycins possess potent antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci. Their structures have been determined by using 1- and 2-D NMR, mass spectroscopy and chemical degradations. Pyrroindomycins are the first natural products that contain the highly unsaturated pyrroloindole moiety.

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