Chlamydia Trachomatis-specific Antibodies in Patients with Pelvic Inflammatory Disease: Comparison with Isolation in Tissue Culture or Detection with Polymerase Chain Reaction

Overview

Journal Genitourin Med

Specialty Infectious Diseases

Date 1994 Oct 1

PMID 8001938

Citations 2

Authors

J J Theunissen

J H Wagenvoort

E Stolz

M F Michel

F J Huikeshoven

Affiliations

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Abstract

Objective: The detection of acute phase antibodies against C trachomatis and its comparison with tissue culture or polymerase chain reaction (PCR) on samples of cervix and urethra obtained from patients with pelvic inflammatory disease (PID).

Methods: In the academic hospital Dijkzigt, Rotterdam, The Netherlands, prospective investigations were performed on 49 consecutive patients who were admitted with the diagnosis of PID. Infections with C trachomatis were traced using tissue culture, PCR or by determining acute phase IgG and IgM antibodies. Differences between the sensitivities of serology and tissue culture or PCR were calculated using the Fisher exact test.

Results: C trachomatis infection was detected more often in PID patients using serology in comparison with PCR (p < 0.05) or tissue culture (p < 0.05). All patients who were positive in tissue culture also had acute phase antibodies.

Conclusion: The establishing of acute C trachomatis infections in PID patients on the basis of serology was superior to either tissue culture or PCR on samples obtained from cervix and urethra.

Citing Articles

Impact of the Levonorgestrel-Releasing Intrauterine System on the Progression of Chlamydia trachomatis Infection to Pelvic Inflammatory Disease in a Baboon Model.

Eastman A, Bergin I, Chai D, Bassis C, LeBar W, Oluoch G J Infect Dis. 2017; 217(4):656-666.

PMID: 29253201 PMC: 5853867. DOI: 10.1093/infdis/jix545.

Periodic health examination, 1996 update: 2. Screening for chlamydial infections. Canadian Task Force on the Periodic Health Examination.

Davies H, Wang E CMAJ. 1996; 154(11):1631-44.

PMID: 8646651 PMC: 1487928.

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