The Myeloneuropathies of Jamaica

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 1994 Apr 1

PMID 7999312

Authors

O St Clair Morgan

Affiliations

Soon will be listed here.

Abstract

This article summarizes the present state of knowledge of TSP/HAM as it is seen in Jamaica. It reviews the historical and clinical aspects of the disease, and shows how the discovery of HTLV-I has generated research in several countries and contributed to a better understanding of the disease. It highlights the need for continued collaboration between basic scientists and clinical neurologists in order that the dilemmas relating to therapy and pathogenicity may be successfully addressed.

References

CRUICKSHANK E . A neuropathic syndrome of uncertain origin; review of 100 cases. West Indian Med J. 1956; 5(3):147-58. View

Gessain A, Gout O . Chronic myelopathy associated with human T-lymphotropic virus type I (HTLV-I). Ann Intern Med. 1992; 117(11):933-46. DOI: 10.7326/0003-4819-117-11-933. View

Kaiser R, Dorries R, ter Meulen J, Kidenya J, Pollath M, Fleischer K . Serologic evidence of human immunodeficiency virus infection of the central nervous system in African patients with acquired immunodeficiency syndrome. Eur Neurol. 1990; 30(1):27-31. DOI: 10.1159/000116621. View

Kramer A, Jacobson S, Reuben J, Murphy E, Wiktor S, Cranston B . Spontaneous lymphocyte proliferation in symptom-free HTLV-I positive Jamaicans. Lancet. 1989; 2(8668):923-4. DOI: 10.1016/s0140-6736(89)91591-2. View

Iwasaki Y . Pathology of chronic myelopathy associated with HTLV-I infection (HAM/TSP). J Neurol Sci. 1990; 96(1):103-23. DOI: 10.1016/0022-510x(90)90060-z. View

Montgomery R, CRUICKSHANK E, Robertson W, McMenemey W . CLINICAL AND PATHOLOGICAL OBSERVATIONS ON JAMAICAN NEUROPATHY; A REPORT ON 206 CASES. Brain. 1964; 87:425-62. DOI: 10.1093/brain/87.3.425. View

Kira J, Itoyama Y, Koyanagi Y, Tateishi J, Kishikawa M, Akizuki S . Presence of HTLV-I proviral DNA in central nervous system of patients with HTLV-I-associated myelopathy. Ann Neurol. 1992; 31(1):39-45. DOI: 10.1002/ana.410310108. View

Itoyama Y, Kira J, Fujii N, Goto I, Yamamoto N . Increases in helper inducer T cells and activated T cells in HTLV-I-associated myelopathy. Ann Neurol. 1989; 26(2):257-62. DOI: 10.1002/ana.410260212. View

Akizuki S, Nakazato O, Higuchi Y, Tanabe K, Setoguchi M, Yoshida S . Necropsy findings in HTLV-I associated myelopathy. Lancet. 1987; 1(8525):156-7. DOI: 10.1016/s0140-6736(87)91984-2. View

10.

Roman G, Schoenberg B, Madden D, Sever J, Hugon J, Ludolph A . Human T-lymphotropic virus type I antibodies in the serum of patients with tropical spastic paraparesis in the Seychelles. Arch Neurol. 1987; 44(6):605-7. DOI: 10.1001/archneur.1987.00520180029011. View

11.

Jacobson S, Shida H, McFarlin D, Fauci A, Koenig S . Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature. 1990; 348(6298):245-8. DOI: 10.1038/348245a0. View

12.

Hirose S, Uemura Y, Fujishita M, Kitagawa T, Yamashita M, Imamura J . Isolation of HTLV-I from cerebrospinal fluid of a patient with myelopathy. Lancet. 1986; 2(8503):397-8. DOI: 10.1016/s0140-6736(86)90081-4. View

13.

Reddy E, Mettus R, DeFreitas E, WROBLEWSKA Z, Cisco M, KOPROWSKI H . Molecular cloning of human T-cell lymphotrophic virus type I-like proviral genome from the peripheral lymphocyte DNA of a patient with chronic neurologic disorders. Proc Natl Acad Sci U S A. 1988; 85(10):3599-603. PMC: 280261. DOI: 10.1073/pnas.85.10.3599. View

14.

Zaninovic V . Spastic paraparesis: a possible sexually transmitted viral myeloneuropathy. Lancet. 1986; 2(8508):697-8. DOI: 10.1016/s0140-6736(86)90217-5. View

15.

Carton H, Kayembe K, Kabeya , Odio , Billiau A, Maertens K . Epidemic spastic paraparesis in Bandundu (Zaire). J Neurol Neurosurg Psychiatry. 1986; 49(6):620-7. PMC: 1028841. DOI: 10.1136/jnnp.49.6.620. View

16.

Gout O, Gessain A, Iba-Zizen M, Kouzan S, Bolgert F, de The G . The effect of zidovudine on chronic myelopathy associated with HTLV-1. J Neurol. 1991; 238(2):108-9. DOI: 10.1007/BF00315691. View

17.

Bartholomew C, Cleghorn F, Charles W, Ratan P, Roberts L, Maharaj K . HTLV-I and tropical spastic paraparesis. Lancet. 1986; 2(8498):99-100. DOI: 10.1016/s0140-6736(86)91626-0. View

18.

Usuku K, Sonoda S, Osame M, Yashiki S, Takahashi K, Matsumoto M . HLA haplotype-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopathy: comparison with adult T-cell leukemia/lymphoma. Ann Neurol. 1988; 23 Suppl:S143-50. DOI: 10.1002/ana.410230733. View

19.

Harrington Jr W, Sheremata W, Snodgrass S, Emerson S, Phillips S, Berger J . Tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM): treatment with an anabolic steroid danazol. AIDS Res Hum Retroviruses. 1991; 7(12):1031-4. DOI: 10.1089/aid.1991.7.1031. View

20.

Francis D, Hughes R . Polymyositis and HTLV-I antibodies. Ann Neurol. 1989; 25(3):311. DOI: 10.1002/ana.410250319. View