The Effect of Hyperglycaemia on the Absorption of Glibenclamide in Patients with Non-insulin-dependent Diabetes Mellitus

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1994 Jan 1

PMID 7988624

Citations 2

Authors

A Hoffman

Y Fischer

D Gilhar

I Raz

Affiliations

Soon will be listed here.

Abstract

We have studied the absorption of glibenclamide 10 mg as a single morning dose in 7 patients with non-insulin-dependent diabetes mellitus, comparing normoglycaemic and hyperglycaemic states. The maximal glibenclamide plasma concentrations were significantly higher in the normoglycaemic than in the hyperglycaemic state (448 vs 228 mg.l-1) and these peak concentrations were attained faster in normoglycaemia than in hyperglycaemia (3.7 vs 5 h). We conclude that the absorption of glibenclamide in the two states is different.

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