Further Investigations on the Mode of Entry of Vaccinia Virus into Cells

Overview

Journal J Gen Virol

Specialty Microbiology

Date 1976 Aug 1

PMID 798024

Citations 52

Authors

A Chang

D H Metz

Affiliations

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Abstract

Earlier results indicating that vaccinia virus entered L cells by a process of direct fusion between the virus envelope and the plasma membrane of the cell have been confirmed and extended using immuno-ferritin conjugates to locate virus antigens on the host cell surface. After fusion, components of the virus envelope become rapidly dispersed in the plasma membrane. Fusion has also been observed as the predominant mode of entry of vaccinia virus into HeLa cells.

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