Normal Volunteers Should Not Be Used for Bioavailability or Bioequivalence Studies of Clozapine

Overview

Journal Pharm Res

Specialties Pharmacology
Pharmacy

Date 1994 Aug 1

PMID 7971728

Citations 4

Authors

R Pokorny

M J FINKEL

W T Robinson

Affiliations

Soon will be listed here.

Citing Articles

Synergic development of pharmacokinetics and bioanalytical methods as support of pharmaceutical research.

Marzo M, Ciccarelli R, Di Iorio P, Giuliani P, Caciagli F, Marzo A Int J Immunopathol Pharmacol. 2015; 29(2):168-79.

PMID: 26684641 PMC: 5806721. DOI: 10.1177/0394632015589531.

The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers.

Othman A, Haig G, Florian H, Locke C, Gertsik L, Dutta S Br J Clin Pharmacol. 2013; 77(6):965-74.

PMID: 24215171 PMC: 4093922. DOI: 10.1111/bcp.12281.

Generic clozapine: a cost-saving alternative to brand name clozapine?.

Tse G, Thompson D, Procyshyn R Pharmacoeconomics. 2002; 21(1):1-11.

PMID: 12484800 DOI: 10.2165/00019053-200321010-00001.

Estimation of the absolute bioavailability of rivastigmine in patients with mild to moderate dementia of the Alzheimer's type.

Hossain M, Jhee S, Shiovitz T, McDonald C, Sedek G, Pommier F Clin Pharmacokinet. 2002; 41(3):225-34.

PMID: 11929322 DOI: 10.2165/00003088-200241030-00006.

References

Saletu B, Grunberger J, Linzmayer L, Anderer P . Comparative placebo-controlled pharmacodynamic studies with zotepine and clozapine utilizing pharmaco-EEG and psychometry. Pharmacopsychiatry. 1987; 20(1 Spec No):12-27. DOI: 10.1055/s-2007-1017125. View