Quantitative Analysis of the Microstructure of the Human Cornea and Sclera Using 2-D Fourier Methods

Overview

Journal J Microsc

Specialty Radiology

Date 1994 Aug 1

PMID 7966254

Citations 5

Authors

S Vaezy

J I Clark

Affiliations

Soon will be listed here.

Abstract

A two-dimensional (2-D) Fourier analysis was used to characterize the microstructure of the human cornea and sclera. The average centre-to-centre spacing of collagen fibrils was found to be 59 nm for the cornea and 285 nm for the sclera. These results agreed with those obtained by direct measurement using the electron micrographs, and those reported in the literature. The spatial order in the microstructure of the cornea was much greater when compared with that of the sclera. The results of the 2-D Fourier analysis were consistent with the theory of transparency of the eye. The 2-D Fourier analysis will be useful in quantitative characterization and analysis of the complex microstructure of biological cells and tissues in normal development and abnormal pathogenesis.

Citing Articles

Quantitative evaluations of vortex vein ampullae by adjusted 3D reverse projection model of ultra-widefield fundus images.

Funatsu R, Terasaki H, Shiihara H, Kawano S, Hirokawa M, Tanabe Y Sci Rep. 2021; 11(1):8916.

PMID: 33903616 PMC: 8076294. DOI: 10.1038/s41598-021-88265-w.

Location and pressure dependent transmission of human and porcine sclera: an anterior to posterior examination.

Koelbl P, Klante P, Koch F, Lingenfelder C, Werner J, Enders C Graefes Arch Clin Exp Ophthalmol. 2017; 255(11):2185-2198.

PMID: 28779364 DOI: 10.1007/s00417-017-3758-y.

Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications.

Edelhauser H, Rowe-Rendleman C, Robinson M, Dawson D, Chader G, Grossniklaus H Invest Ophthalmol Vis Sci. 2010; 51(11):5403-20.

PMID: 20980702 PMC: 3061492. DOI: 10.1167/iovs.10-5392.

Analysis of nuclear fiber cell cytoplasmic texture in advanced cataractous lenses from Indian subjects using Debye-Bueche theory.

Metlapally S, Costello M, Gilliland K, Ramamurthy B, Krishna P, Balasubramanian D Exp Eye Res. 2008; 86(2):434-44.

PMID: 18191834 PMC: 2366113. DOI: 10.1016/j.exer.2007.11.018.

Nanostructure predicts intraspecific variation in ultraviolet-blue plumage colour.

Shawkey M, Estes A, Siefferman L, Hill G Proc Biol Sci. 2003; 270(1523):1455-60.

PMID: 12965009 PMC: 1691395. DOI: 10.1098/rspb.2003.2390.