Promotion of Remyelination by Polyclonal Immunoglobulin in Theiler's Virus-induced Demyelination and in Multiple Sclerosis

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1994 Nov 1

PMID 7964859

Citations 11

Authors

B G van Engelen

D J Miller

K D Pavelko

O R Hommes

M Rodriguez

Affiliations

Soon will be listed here.

Abstract

Spontaneous remyelination occurs in experimental models of demyelination and in patients with multiple sclerosis, although to a limited extent. This enables the search for factors that promote remyelination. Using the Theiler's virus model of central nervous system demyelination, promotion of remyelination was observed after passive transfer of CNS-specific antiserum and transfer of CNS-specific purified immunoglobulin. Mouse polyclonal immunoglobulin from normal non-syngeneic mice, comparable with the human immunoglobulin preparation, also promotes CNS remyelination in the Theiler's virus model of multiple sclerosis. These experimental findings further bridge the gap with a pilot study that suggests clinical improvement after polyclonal immunoglobulin administration, possibly due to remyelination, in some multiple sclerosis patients with stable, steroid-unresponsive optic neuritis. In view of these experimental and clinical data, the physiological role of myelin in demyelination and remyelination is discussed, and the role of IgG solely as a deleterious molecule in the pathophysiology of multiple sclerosis and experimental demyelination is addressed.

Citing Articles

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Impact of Immunoglobulin Therapy in Pediatric Disease: a Review of Immune Mechanisms.

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Treatment of spinal cord injury with intravenous immunoglobulin G: preliminary evidence and future perspectives.

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B-cell targeting agents in the treatment of multiple sclerosis.

Braley T, Segal B Curr Treat Options Neurol. 2013; 15(3):259-69.

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Current proposed mechanisms of action of intravenous immunoglobulins in inflammatory neuropathies.

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