HIV-particles in Spermatozoa of Patients with AIDS and Their Transfer into the Oocyte

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 1994 Nov 1

PMID 7962075

Citations 19

Authors

B Baccetti

A Benedetto

A G Burrini

G Collodel

E C Ceccarini

N Crisa

A Di Caro

M Estenoz

A R Garbuglia

A Massacesi

Affiliations

Soon will be listed here.

Abstract

By immunocytochemistry and in situ hybridization at the electron microscopy level, and by the PCR technique, we have shown that HIV-1 binds and enters normal sperm; that viral particles, their antigens, and nucleic acid are present in sperm from HIV-1 infected men; and that such sperm can transfer HIV-1 like particles to normal human oocytes. We also present evidence that a galactosylceramide-like compound is present on the sperm membrane and could function as an alternative receptor for HIV.

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