Spine Deformity Index in Osteoporotic Women: Relations to Forearm and Vertebral Bone Mineral Measurements and to Iliac Crest Ash Density

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 1994 Jul 1

PMID 7949751

Authors

C H Sogaard

A P Hermann

C Hasling

L Mosekilde

Affiliations

Soon will be listed here.

Abstract

Bone densitometric measurements are widely used for monitoring therapeutic regimens for osteoporosis. However, it is a matter of debate which measurement site is most appropriate for prediction of individual fracture risk. The aim of this cross-sectional study was to investigate the relationship between bone mineral measurements at various sites and spine deformity index (SDI) in osteoporotic women. The SDI was determined in 37 osteoporotic women aged 56-87 years (mean 70.9 years). Peripheral (single-photon absorptiometry of the distal forearm, and iliac crest ash content) and axial (dual-photon absorptiometry of the lumbar spine) bone mass measurements were obtained. SDI increased with age (r = 0.34, p < 0.05), whereas forearm BMC (r = -0.52, p < 0.002) and forearm BMD (r = -0.62, p < 0.0001) decreased. No significant age-related changes were observed in lumbar BMC or iliac crest ash content in these osteoporotic women. A highly significant correlation was found between SDI and lumbar BMC (r = -0.60, p < 0.01). A significant, but less pronounced correlation was found between SDI and forearm BMC (r = -0.37, p < 0.05), whereas no relation was revealed between SDI and forearm BMD or iliac crest ash content. In a multiple regression model, the relationship between lumbar BMC and SDI remained significant after adjusting for the influence of age, whereas the relationship to forearm BMC disappeared. Furthermore, a multiple regression analysis was performed in order to evaluate the ability of all four bone mass measurements and age to predict variations in SDI.(ABSTRACT TRUNCATED AT 250 WORDS)

References

Cummings S, Black D, Nevitt M, Browner W, Cauley J, Ensrud K . Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet. 1993; 341(8837):72-5. DOI: 10.1016/0140-6736(93)92555-8. View

Melton 3rd L, Kan S, Frye M, Wahner H, OFallon W, Riggs B . Epidemiology of vertebral fractures in women. Am J Epidemiol. 1989; 129(5):1000-11. DOI: 10.1093/oxfordjournals.aje.a115204. View

Mazess R, Peppler W, Chesney R, Lange T, Lindgren U, Smith Jr E . Does bone measurement on the radius indicate skeletal status? Concise communication. J Nucl Med. 1984; 25(3):281-8. View

Wasnich R, Ross P, Davis J, Vogel J . A comparison of single and multi-site BMC measurements for assessment of spine fracture probability. J Nucl Med. 1989; 30(7):1166-71. View

HURXTHAL L . Measurement of anterior vertebral compressions and biconcave vertebrae. Am J Roentgenol Radium Ther Nucl Med. 1968; 103(3):635-44. DOI: 10.2214/ajr.103.3.635. View

Barnett E, Nordin B . The radiological diagnosis of osteoporosis: a new approach. Clin Radiol. 1960; 11:166-74. DOI: 10.1016/s0009-9260(60)80012-8. View

Ross P, Yhee Y, He Y, Davis J, Kamimoto C, Epstein R . A new method for vertebral fracture diagnosis. J Bone Miner Res. 1993; 8(2):167-74. DOI: 10.1002/jbmr.5650080207. View

Krolner B . Lumbar spine bone mineral content by photon beam absorptiometry. Methodology and application in osteoporosis. Dan Med Bull. 1985; 32(3):152-70. View

Bernecker P, Pietschmann P, Winkelbauer F, Krexner E, Resch H, Willvonseder R . The spine deformity index in osteoporosis is not related to bone mineral and ultrasound measurements. Br J Radiol. 1992; 65(773):393-6. DOI: 10.1259/0007-1285-65-773-393. View

10.

Pocock N, Eisman J, Yeates M, Sambrook P, Eberl S, Wren B . Limitations of forearm bone densitometry as an index of vertebral or femoral neck osteopenia. J Bone Miner Res. 1986; 1(4):369-75. DOI: 10.1002/jbmr.5650010410. View

11.

Wahner H, Dunn W, Riggs B . Noninvasive bone mineral measurements. Semin Nucl Med. 1983; 13(3):282-9. DOI: 10.1016/s0001-2998(83)80021-x. View

12.

Nilas L, Podenphant J, Riis B, Gotfredsen A, Christiansen C . Usefulness of regional bone measurements in patients with osteoporotic fractures of the spine and distal forearm. J Nucl Med. 1987; 28(6):960-5. View

13.

Ross P, Wasnich R, Vogel J . Detection of prefracture spinal osteoporosis using bone mineral absorptiometry. J Bone Miner Res. 1988; 3(1):1-11. DOI: 10.1002/jbmr.5650030103. View

14.

Nordin B, Need A, Chatterton B, Horowitz M, Morris H . The relative contributions of age and years since menopause to postmenopausal bone loss. J Clin Endocrinol Metab. 1990; 70(1):83-8. DOI: 10.1210/jcem-70-1-83. View

15.

Sauer P, Leidig G, Minne H, Duckeck G, Schwarz W, Siromachkostov L . Spine deformity index (SDI) versus other objective procedures of vertebral fracture identification in patients with osteoporosis: a comparative study. J Bone Miner Res. 1991; 6(3):227-38. DOI: 10.1002/jbmr.5650060304. View

16.

Ross P, Davis J, Epstein R, Wasnich R . Pre-existing fractures and bone mass predict vertebral fracture incidence in women. Ann Intern Med. 1991; 114(11):919-23. DOI: 10.7326/0003-4819-114-11-919. View

17.

Hansen M, Riis B, Overgaard K, Hassager C, Christiansen C . Bone mass measured by photon absorptiometry: comparison of forearm, heel, and spine. Scand J Clin Lab Invest. 1990; 50(5):517-23. DOI: 10.1080/00365519009089166. View

18.

Seeman E, Martin T . Non-invasive techniques for the measurement of bone mineral. Baillieres Clin Endocrinol Metab. 1989; 3(1):1-33. DOI: 10.1016/s0950-351x(89)80021-7. View

19.

Riggs B, Wahner H, Seeman E, Offord K, Dunn W, Mazess R . Changes in bone mineral density of the proximal femur and spine with aging. Differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest. 1982; 70(4):716-23. PMC: 370279. DOI: 10.1172/jci110667. View

20.

Nordin B, Need A, Bridges A, Horowitz M . Relative contributions of years since menopause, age, and weight to vertebral density in postmenopausal women. J Clin Endocrinol Metab. 1992; 74(1):20-3. DOI: 10.1210/jcem.74.1.1727821. View