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Neurological Illness Following Treatment with Fludarabine

Overview
Journal Br J Cancer
Specialty Oncology
Date 1994 Nov 1
PMID 7947105
Citations 4
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Abstract

Fludarabine is a comparatively new drug for the treatment of low-grade lymphoid malignancy. This report describes five cases of unusual neurological illnesses occurring after treatment with fludarabine. These suggest that caution should be exercised in patients receiving fludarabine who develop neurological abnormalities, with prompt investigation and if necessary cessation of the drug.

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References
1.
Suzuki J, Takaku A . Cerebrovascular "moyamoya" disease. Disease showing abnormal net-like vessels in base of brain. Arch Neurol. 1969; 20(3):288-99. DOI: 10.1001/archneur.1969.00480090076012. View

2.
Warrell Jr R, Berman E . Phase I and II study of fludarabine phosphate in leukemia: therapeutic efficacy with delayed central nervous system toxicity. J Clin Oncol. 1986; 4(1):74-9. DOI: 10.1200/JCO.1986.4.1.74. View

3.
Spriggs D, Stopa E, Mayer R, SCHOENE W, Kufe D . Fludarabine phosphate (NSC 312878) infusions for the treatment of acute leukemia: phase I and neuropathological study. Cancer Res. 1986; 46(11):5953-8. View

4.
Chun H, Caryk S, Hoth D . Central nervous system toxicity of fludarabine phosphate. Cancer Treat Rep. 1986; 70(10):1225-8. View

5.
Merkel D, Griffin N, Von Hoff D . Central nervous system toxicity with fludarabine. Cancer Treat Rep. 1986; 70(12):1449-50. View