Alpha 2.0
Login Register
» Articles » PMID: 7945724

Probing the Active Site and Mechanism of Action of O6-methylguanine-DNA Methyltransferase with Substrate Analogues (O6-substituted Guanines)

Overview
Journal Anticancer Drug Des
Publisher Oxford University Press
Specialties Oncology
Pharmacology
Date 1994 Oct 1
PMID 7945724
Citations 5
Authors
C E Arris
C Bleasdale
A H Calvert
N J Curtin
C Dalby
B T Golding
R J Griffin
J M Lunn
G N Major
D R Newell
Affiliations
Soon will be listed here.
Citing Articles

Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.

Pletsas D, Garelnabi E, Li L, Phillips R, Wheelhouse R J Med Chem. 2013; 56(17):7120-32.

PMID: 23895620 PMC: 4219134. DOI: 10.1021/jm401121k.

6-Oxo and 6-thio purine analogs as antimycobacterial agents.

Pathak A, Pathak V, Seitz L, Suling W, Reynolds R Bioorg Med Chem. 2013; 21(7):1685-95.

PMID: 23434367 PMC: 3612542. DOI: 10.1016/j.bmc.2013.01.054.

Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase.

Wibley J, Pegg A, Moody P Nucleic Acids Res. 1999; 28(2):393-401.

PMID: 10606635 PMC: 102527. DOI: 10.1093/nar/28.2.393.

Recombinant human O6-alkylguanine-DNA alkyltransferase (AGT), Cys145-alkylated AGT and Cys145 --> Met145 mutant AGT: comparison by isoelectric focusing, CD and time-resolved fluorescence spectroscopy.

Federwisch M, Hassiepen U, Bender K, Dewor M, Rajewsky M, Wollmer A Biochem J. 1997; 324 ( Pt 1):321-8.

PMID: 9164873 PMC: 1218433. DOI: 10.1042/bj3240321.

Binding and repair of O6-ethylguanine in double-stranded oligodeoxynucleotides by recombinant human O6-alkylguanine-DNA alkyltransferase do not exhibit significant dependence on sequence context.

Bender K, Federwisch M, Loggen U, Nehls P, Rajewsky M Nucleic Acids Res. 1996; 24(11):2087-94.

PMID: 8668540 PMC: 145916. DOI: 10.1093/nar/24.11.2087.