The 2A Proteinase of Human Rhinovirus is a Zinc Containing Enzyme

Overview

Journal Virology

Specialty Microbiology

Date 1994 Nov 1

PMID 7941352

Citations 17

Authors

W Sommergruber

G Casari

F FESSL

J Seipelt

T Skern

Affiliations

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Abstract

The 2A proteinase of human rhinovirus (HRV) 2 is a cysteine proteinase which is not inhibited by metal chelating agents. However, total hydrolysis of highly purified HRV2 2A followed by atom emission spectroscopy demonstrated that HRV2 2A contains 1 mol of zinc per mole of enzyme. Furthermore, Zn depletion of the enzyme led to a loss of proteolytic activity which could subsequently be restored by Zn supplementation.

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