Hepatic Clearance of Candida Albicans in Rats

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1976 Dec 1

PMID 793993

Citations 16

Authors

R T Sawyer

R J Moon

E S BENEKE

Affiliations

Soon will be listed here.

Abstract

The initial clearance of Candida albicans from the blood stream of rats and from perfusion medium by perfused rat livers was characterized. Normal rats cleared over 90% of large doses of intravenously injected yeast cells in 5 min. All were recovered as viable cells among various reticulendothelial organs after 30 min. The perfused rat liver trapped an average of 85% of the yeast cells in a single pass. No significant killing occurred, even in the presence of 10% whole rat blood. Scanning electron microscopy of cryofractured livers revealed that the cells were trapped in liver sinusoids but outside phagocytic cells.

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Protection of Candida parapsilosis from neutrophil killing through internalization by human endothelial cells.

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Candida albicans increases tumor cell adhesion to endothelial cells in vitro: intraspecific differences and importance of the mannose receptor.

Ramirez-Garcia A, Arteta B, Abad-Diaz-de-Cerio A, Pellon A, Antoran A, Marquez J PLoS One. 2013; 8(1):e53584.

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Mannose binding protein is involved in first-line host defence: evidence from transgenic mice.

Tabona P, Mellor A, Summerfield J Immunology. 1995; 85(1):153-9.

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Trapping and killing of Candida albicans by Corynebacterium parvum-activated livers.

Sawyer R, Moon R, BENEKE E Infect Immun. 1981; 32(2):945-50.

PMID: 7019084 PMC: 351533. DOI: 10.1128/iai.32.2.945-950.1981.

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