The HSSP Database of Protein Structure-sequence Alignments
Overview
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HSSP (homology-derived structures of proteins) is a derived database merging structural (2-D and 3-D) and sequence information (1-D). For each protein of known 3D structure from the Protein Data Bank, the database has a file with all sequence homologues, properly aligned to the PDB protein. Homologues are very likely to have the same 3D structure as the PDB protein to which they have been aligned. As a result, the database is not only a database of sequence aligned sequence families, but it is also a database of implied secondary and tertiary structures.
nT4X and nT4M: Novel Time Non-reversible Mixture Amino Acid Substitution Models.
Tinh N, Dang C, Vinh L J Mol Evol. 2025; 93(1):136-148.
PMID: 39832000 DOI: 10.1007/s00239-024-10230-8.
Is Over-parameterization a Problem for Profile Mixture Models?.
Banos H, Susko E, Roger A Syst Biol. 2023; 73(1):53-75.
PMID: 37843172 PMC: 11129589. DOI: 10.1093/sysbio/syad063.
Spectrum of Protein Location in Proteomes Captures Evolutionary Relationship Between Species.
Marot-Lassauzaie V, Goldberg T, Almagro Armenteros J, Nielsen H, Rost B J Mol Evol. 2021; 89(8):544-553.
PMID: 34328525 PMC: 8379119. DOI: 10.1007/s00239-021-10022-4.
LAHMA: structure analysis through local annotation of homology-matched amino acids.
Van Beusekom B, Damaskos G, Hekkelman M, Salgado-Polo F, Hiruma Y, Perrakis A Acta Crystallogr D Struct Biol. 2021; 77(Pt 1):28-40.
PMID: 33404523 PMC: 7787103. DOI: 10.1107/S2059798320014473.
Trollope K, Gorgens J, Volschenk H Appl Environ Microbiol. 2015; 81(20):7319-29.
PMID: 26253664 PMC: 4579456. DOI: 10.1128/AEM.02134-15.