Frequency of Deletion Formation Decreases Exponentially with Distance Between Short Direct Repeats

Overview

Journal Mol Microbiol

Specialties Microbiology
Molecular Biology

Date 1994 May 1

PMID 7934879

Citations 40

Authors

F Chedin

E Dervyn

R Dervyn

S D Ehrlich

P Noirot

Affiliations

Soon will be listed here.

Abstract

The effect of distance between 18 bp direct repeats on deletion formation has been examined in Bacillus subtilis. The deletion frequency decreased exponentially by more than 1000-fold as the distance increased from 33 to 2313 bp. This decrease occurred in two distinct phases, which may be determined by DNA-duplex flexibility. A similar relationship between deletion formation and distance was observed in a theta-replicating plasmid and in the chromosome, indicating that this relationship might have a general validity.

Citing Articles

Deletions across the SARS-CoV-2 Genome: Molecular Mechanisms and Putative Functional Consequences of Deletions in Accessory Genes.

Rogozin I, Saura A, Bykova A, Brover V, Yurchenko V Microorganisms. 2023; 11(1).

PMID: 36677521 PMC: 9862619. DOI: 10.3390/microorganisms11010229.

RecA-independent recombination: Dependence on the Escherichia coli RarA protein.

Jain K, Wood E, Romero Z, Cox M Mol Microbiol. 2020; 115(6):1122-1137.

PMID: 33247976 PMC: 8160026. DOI: 10.1111/mmi.14655.

Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins.

Romero Z, Armstrong T, Henrikus S, Chen S, Glass D, Ferrazzoli A Nucleic Acids Res. 2019; 48(1):212-230.

PMID: 31665437 PMC: 7145654. DOI: 10.1093/nar/gkz960.

Template-switching during replication fork repair in bacteria.

Lovett S DNA Repair (Amst). 2017; 56:118-128.

PMID: 28641943 PMC: 5538584. DOI: 10.1016/j.dnarep.2017.06.014.

Dynamic Expansion and Contraction of Copy Number in Impact Development of Gastric Disease.

Jang S, Su H, Blum F, Bae S, Choi Y, Kim A mBio. 2017; 8(1).

PMID: 28223454 PMC: 5358911. DOI: 10.1128/mBio.01779-16.