Some Interrelations of Neutrophil Chemotaxis, Lysosomal Enzyme Secretion, and Phagocytosis As Revealed by Synthetic Peptides

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1976 Nov 1

PMID 793409

Citations 33

Authors

E L Becker

Affiliations

Soon will be listed here.

Abstract

Synthetic oligopeptides of appropriate structure stimulate neutrophil random locomotion, chemotaxis, lysosomal enzyme secretion, and phagocytosis. The structure-activity relationships found for enhanced migration and lysosomal enzyme secretion strongly suggest that the peptides bind to a structurally specific receptor on the neutrophil surface. It is further suggested that the binding of a peptide to the same receptor initiates all of these neutrophil functions. It is postulated that this is accomplished by the receptor-peptide combination initiating a series of parallel but coordinated and interdependent biochemical sequences leading to either microfilament or microtubule activation in addition to other processes. The various functions of the neutrophil differentially utilize the microfilament and microtubule systems.

Citing Articles

Metabolism: a potential regulator of neutrophil fate.

Yipeng Z, Chao C, Ranran L, Tingting P, Hongping Q Front Immunol. 2024; 15():1500676.

PMID: 39697327 PMC: 11652355. DOI: 10.3389/fimmu.2024.1500676.

A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination.

Konig M, Andrade F Front Immunol. 2016; 7:461.

PMID: 27867381 PMC: 5095114. DOI: 10.3389/fimmu.2016.00461.

Movement within and movement beyond: synaptotagmin-mediated vesicle fusion during chemotaxis.

Colvin R, Luster A Cell Adh Migr. 2010; 5(1):56-8.

PMID: 20798599 PMC: 3038099. DOI: 10.4161/cam.5.1.13197.

Neopeptide antibiotics that function as opsonins and membrane-permeabilizing agents for gram-negative bacteria.

Tsubery H, Yaakov H, Cohen S, Giterman T, Matityahou A, Fridkin M Antimicrob Agents Chemother. 2005; 49(8):3122-8.

PMID: 16048913 PMC: 1196242. DOI: 10.1128/AAC.49.8.3122-3128.2005.

Levels of IL-8 and myeloperoxidase in the lungs of pneumonia patients.

Abul H, Abul A, Khan I, Mathew T, Ayed A Mol Cell Biochem. 2001; 217(1-2):107-12.

PMID: 11269653 PMC: 7102223. DOI: 10.1023/a:1007264411006.

References

Becker E, Showell H, Henson P, Hsu L . The ability of chemotactic factors to induce lysosomal enzyme release. I. The characteristics of the release, the importance of surfaces and the relation of enzyme release to chemotactic responsiveness. J Immunol. 1974; 112(6):2047-54. View

Schiffmann E, CORCORAN B, Wahl S . N-formylmethionyl peptides as chemoattractants for leucocytes. Proc Natl Acad Sci U S A. 1975; 72(3):1059-62. PMC: 432465. DOI: 10.1073/pnas.72.3.1059. View

Zigmond S, Hirsch J . Effects of cytochalasin B on polymorphonuclear leucocyte locomotion, phagocytosis and glycolysis. Exp Cell Res. 1972; 73(2):383-93. DOI: 10.1016/0014-4827(72)90062-6. View

Becker E, Henson P . In vitro studies of immunologically induced secretion of mediators from cells and related phenomena. Adv Immunol. 1973; 17:93-193. DOI: 10.1016/s0065-2776(08)60732-4. View

Gallin J, Rosenthal A . The regulatory role of divalent cations in human granulocyte chemotaxis. Evidence for an association between calcium exchanges and microtubule assembly. J Cell Biol. 1974; 62(3):594-609. PMC: 2109215. DOI: 10.1083/jcb.62.3.594. View

Pollard T, Weihing R . Actin and myosin and cell movement. CRC Crit Rev Biochem. 1974; 2(1):1-65. DOI: 10.3109/10409237409105443. View

Becker E, Davis A, Estensen R, Quie P . Cytochalasin B. IV. Inhibition and stimulation of chemotaxis of rabbit and human polymorphonuclear leukocytes. J Immunol. 1972; 108(2):396-402. View

Zurier R, Hoffstein S, Weissmann G . Cytochalasin B: effect on lysosomal enzyme release from human leukocytes. Proc Natl Acad Sci U S A. 1973; 70(3):844-8. PMC: 433372. DOI: 10.1073/pnas.70.3.844. View

Stossel T, Mason R, Hartwig J, Vaughan M . Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis. J Clin Invest. 1972; 51(3):615-24. PMC: 302168. DOI: 10.1172/JCI106851. View

10.

Henson P . Pathologic mechanisms in neutrophil-mediated injury. Am J Pathol. 1972; 68(3):593-612. PMC: 2032754. View

11.

Boxer L, Hedley-Whyte E, Stossel T . Neutrophil actin dysfunction and abnormal neutrophil behavior. N Engl J Med. 1974; 291(21):1093-9. DOI: 10.1056/NEJM197411212912101. View

12.

Ramsey W, Harris A . Leucocyte locomotion and its inhibition by antimitotic drugs. Exp Cell Res. 1973; 82(2):262-70. DOI: 10.1016/0014-4827(73)90340-6. View

13.

Zigmond S, Hirsch J . Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor. J Exp Med. 1973; 137(2):387-410. PMC: 2139498. DOI: 10.1084/jem.137.2.387. View

14.

Lehrer R . Effects of colchicine and chloramphenicol on the oxidative metabolism and phagocytic activity of human neutrophils. J Infect Dis. 1973; 127(1):40-8. DOI: 10.1093/infdis/127.1.40. View

15.

Weissmann G, Goldstein I, Hoffstein S, Tsung P . Reciprocal effects of cAMP and cGMP on microtubule-dependent release of lysosomal enzymes. Ann N Y Acad Sci. 1975; 253:750-62. DOI: 10.1111/j.1749-6632.1975.tb19243.x. View

16.

Stossel T . Phagocytosis: recognition and ingestion. Semin Hematol. 1975; 12(1):83-116. View

17.

Oliver J, Zurier R, BERLIN R . Concanavalin a cap formation on polymorphonuclear leukocytes of normal and beige (chediak-higashi) mice. Nature. 1975; 253(5491):471-3. DOI: 10.1038/253471a0. View

18.

Cannarozzi N, Malawista S . Phagocytosis by human blood leukocytes measured by the uptake of 131I-labeled human serum albumin: inhibitory and stimulatory effects of cytochalasin B. Yale J Biol Med. 1973; 46(3):177-89. PMC: 2591976. View

19.

Becker E, Showell H . The ability of chemotactic factors to induce lysosomal enzyme release. II. The mechanism of release. J Immunol. 1974; 112(6):2055-62. View

20.

Stossel T, Root R, Vaughan M . Phagocytosis in chronic granulomatous disease and the Chediak-Higashi syndrome. N Engl J Med. 1972; 286(3):120-3. DOI: 10.1056/NEJM197201202860302. View