The Regulatory Switch of the Muscle Thin Filament: Ca2+ or Myosin Heads?

Overview

Journal J Muscle Res Cell Motil

Specialties Cell Biology
Physiology

Date 1994 Jun 1

PMID 7929789

Citations 62

Authors

S S Lehrer

Affiliations

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Abstract

Ca2+ and myosin heads are both involved in regulation, with Ca2+ as the allosteric trigger and the myosin head-induced Tm off-on transition as the switch. The allosteric/cooperative model is a good phenomenological description of part of the process and aspects of the original steric blocking model are involved in the molecular mechanisms.

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