Sister Chromatid Exchanges in Workers Employed in Car-painting Workshops

Overview

Journal Int Arch Occup Environ Health

Specialty Environmental Health

Date 1994 Jan 1

PMID 7927840

Authors

S Sardas

A E Karakaya

Y Furtun

Affiliations

Soon will be listed here.

Abstract

Car painting workers are exposed to a number of potentially genotoxic agents. The frequencies of sister chromatid exchanges (SCEs) were determined in a group of 22 workers involved in painting repaired cars in small workshops. An occupationally non-exposed age-matched group served as controls. There was a significant difference (P < 0.001) in the mean SCE levels in exposed (7.81 +/- 1.50) and non-exposed (4.92 +/- 0.10) groups. Smoking habit was the other factor most influencing SCE levels. Among both the exposed workers and the controls, smokers had a higher SCE frequency than non-smokers.

References

Kelsey K, Wiencke J, Little F, Baker Jr E, Little J . Sister chromatid exchange in painters recently exposed to solvents. Environ Res. 1989; 50(2):248-55. DOI: 10.1016/s0013-9351(89)80005-2. View

Stockwell H, Matanoski G . A case-control study of lung cancer in painters. J Occup Med. 1985; 27(2):125-6. View

Roberts A, Bogdanffy M, Brown D, Schatz R . Lung metabolism of benzo[a]pyrene in rats treated with p-xylene and/or ethanol. J Toxicol Environ Health. 1986; 18(2):257-66. DOI: 10.1080/15287398609530866. View

Maki-Paakkanen J, Husgafvel-Pursiainen K, Kalliomaki P, Tuominen J, Sorsa M . Toluene-exposed workers and chromosome aberrations. J Toxicol Environ Health. 1980; 6(4):775-81. DOI: 10.1080/15287398009529896. View

Hjelm E, Naslund P, Wallen M . Influence of cigarette smoking on the toxicokinetics of toluene in humans. J Toxicol Environ Health. 1988; 25(2):155-63. DOI: 10.1080/15287398809531197. View

Kato H . Induction of sister chromatid exchanges by chemical mutagens and its possible relevance to DNA repair. Exp Cell Res. 1974; 85(2):239-47. DOI: 10.1016/0014-4827(74)90123-2. View

Sarto F, Mustari L, Mazzotti D, Tomanin R, LEVIS A . Variations of SCE frequencies in peripheral lymphocytes of ex-smokers. Mutat Res. 1987; 192(2):157-62. DOI: 10.1016/0165-7992(87)90114-x. View

Matanoski G, Stockwell H, Diamond E, Joffe R, Mele L, Johnson M . A cohort mortality study of painters and allied tradesmen. Scand J Work Environ Health. 1986; 12(1):16-21. DOI: 10.5271/sjweh.2179. View

van Sittert N, de Jong G . Biomonitoring of exposure to potential mutagens and carcinogens in industrial populations. Food Chem Toxicol. 1985; 23(1):23-31. DOI: 10.1016/0278-6915(85)90216-9. View

10.

Elofsson S, Gamberale F, Hindmarsh T, Iregren A, Isaksson A, Johnsson I . Exposure to organic solvents. A cross-sectional epidemiologic investigation on occupationally exposed care and industrial spray painters with special reference to the nervous system. Scand J Work Environ Health. 1980; 6(4):239-73. DOI: 10.5271/sjweh.2609. View

11.

Kawai T, Yasugi T, Mizunuma K, Horiguchi S, Morioka I, Miyashita K . Monitoring of workers exposed to a mixture of toluene, styrene and methanol vapours by means of diffusive air sampling, blood analysis and urinalysis. Int Arch Occup Environ Health. 1992; 63(6):429-35. DOI: 10.1007/BF00386940. View

12.

Wolff S . Difficulties in assessing the human health effect of mutagenic carcinogens by cytogenetic analyses. Cytogenet Cell Genet. 1982; 33(1-2):7-13. DOI: 10.1159/000131719. View

13.

Sardas S, Gok S, Karakaya A . Increased frequency of sister chromatid exchanges in the peripheral lymphocytes of cigarette smokers. Toxicol In Vitro. 2010; 5(3):263-5. DOI: 10.1016/0887-2333(91)90027-b. View

14.

Wallen M . Toxicokinetics of toluene in occupationally exposed volunteers. Scand J Work Environ Health. 1986; 12(6):588-93. View

15.

Perry P, Wolff S . New Giemsa method for the differential staining of sister chromatids. Nature. 1974; 251(5471):156-8. DOI: 10.1038/251156a0. View

16.

Ghosh R, Ghosh P . The effect of tobacco smoking on the frequency of sister chromatid exchanges in human lymphocyte chromosomes. Cancer Genet Cytogenet. 1987; 27(1):15-9. DOI: 10.1016/0165-4608(87)90254-8. View

17.

LATT S, Allen J, Bloom S, Carrano A, Falke E, Kram D . Sister-chromatid exchanges: a report of the GENE-TOX program. Mutat Res. 1981; 87(1):17-62. DOI: 10.1016/0165-1110(81)90003-8. View

18.

Evans H . Chromosomal mutations in human populations. Cytogenet Cell Genet. 1982; 33(1-2):48-56. DOI: 10.1159/000131725. View

19.

Watanabe T, Endo A, Kumai M, Ikeda M . Chromosome aberrations and sister chromatid exchanges in styrene-exposed workers with reference to their smoking habits. Environ Mutagen. 1983; 5(3):299-309. DOI: 10.1002/em.2860050308. View

20.

Sardas S, Cuhruk H, Karakaya A, Atakurt Y . Sister-chromatid exchanges in operating room personnel. Mutat Res. 1992; 279(2):117-20. DOI: 10.1016/0165-1218(92)90253-v. View