Phage Display of a Human Antibody Against Clostridium Tetani Toxin
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Abstract
9F12, a human antibody capable of neutralising tetanus toxin in an animal model, has been expressed as a Fab fragment in a phagemid system. The nucleotide sequence for the variable domain of both chains has been determined and compared to germline sequences.
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On the influence of vector design on antibody phage display.
Soltes G, Hust M, Ng K, Bansal A, Field J, Stewart D J Biotechnol. 2006; 127(4):626-37.
PMID: 16996161 PMC: 1866265. DOI: 10.1016/j.jbiotec.2006.08.015.