Structural and Functional Characterization of the Rod Outer Segment Membrane Guanylate Cyclase

Overview

Journal Biochem J

Specialty Biochemistry

Date 1994 Sep 1

PMID 7916565

Citations 50

Authors

R M Goraczniak

T Duda

A Sitaramayya

R K Sharma

Affiliations

Soon will be listed here.

Abstract

In the vertebrate photoreceptor cell, rod outer segment (ROS) is the site of visual signal-transduction process, and a pivotal molecule that regulates this process is cyclic GMP. Cyclic GMP controls the cationic conductance into the ROS, and light causes a decrease in the conductance by activating hydrolysis of the cyclic nucleotide. The identity of the granylate cyclase (ROS-GC) that synthesizes this pool of cyclic GMP is unknown. We now report the cloning, expression and functional characterization of a DNA from bovine retina that encodes ROS-GC.

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