Interactions of Gamma-L-glutamyltaurine with Excitatory Aminoacidergic Neurotransmission

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1994 Mar 1

PMID 7909918

Citations 7

Authors

V Varga

R Janaky

K M Marnela

P Saransaari

S S Oja

Affiliations

Soon will be listed here.

Abstract

The in vitro effects of gamma-L-glutamyltaurine on different stages of excitatory aminoacidergic neurotransmission were tested with gamma-D-glutamyltaurine as reference. gamma-L-Glutamyltaurine enhanced the K(+)-stimulated release of [3H]glutamate from cerebral cortical slices (25% at 0.1 mM) and slightly inhibited the uptake by crude brain synaptosomal preparations (about 10% at 1 mM). gamma-L-Glutamyltaurine was also a weak displacer of glutamate and its agonists from their binding sites in brain synaptic membrane preparations, being, however, less selective to quisqualate (QA) sites than gamma-D-glutamyltaurine. The basal influx of Ca2+ into cultured cerebellar granular cells was not affected by 1 mM gamma-L-glutamyltaurine, but the glutamate- and its agonist-activated influx was significantly inhibited in low-Mg2+ (0.1 mM) and Mg(2+)-free media. The glutamate-evoked increase in free intracellular Ca2+ and the kainate-activated formation of cGMP in cerebellar slices were both markedly inhibited by 0.1 mM gamma-L-glutamyltaurine. We propose that gamma-L-glutamyltaurine may act as endogenous modulator in excitatory aminoacidergic neurotransmission.

Citing Articles

The Emerging Roles of γ-Glutamyl Peptides Produced by γ-Glutamyltransferase and the Glutathione Synthesis System.

Ikeda Y, Fujii J Cells. 2023; 12(24).

PMID: 38132151 PMC: 10741565. DOI: 10.3390/cells12242831.

Critical Roles of the Cysteine-Glutathione Axis in the Production of γ-Glutamyl Peptides in the Nervous System.

Fujii J, Osaki T, Soma Y, Matsuda Y Int J Mol Sci. 2023; 24(9).

PMID: 37175751 PMC: 10179188. DOI: 10.3390/ijms24098044.

Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms.

Jakaria M, Azam S, Haque M, Jo S, Uddin M, Kim I Redox Biol. 2019; 24:101223.

PMID: 31141786 PMC: 6536745. DOI: 10.1016/j.redox.2019.101223.

Advances in drug design based on the amino Acid approach: taurine analogues for the treatment of CNS diseases.

Chung M, Malatesta P, Bosquesi P, Yamasaki P, Dos Santos J, Vizioli E Pharmaceuticals (Basel). 2013; 5(10):1128-46.

PMID: 24281261 PMC: 3816653. DOI: 10.3390/ph5101128.

Interference of S-alkyl derivatives of glutathione with brain ionotropic glutamate receptors.

Jenei Z, Janaky R, Varga V, Saransaari P, Oja S Neurochem Res. 1998; 23(8):1085-91.

PMID: 9704598 DOI: 10.1023/a:1020712203611.

References

Kuribara H, Tadokoro S . An anticonflict effect of gamma-1-glutamyltaurine (Litoralon) in rats. Jpn J Pharmacol. 1982; 32(6):1067-74. DOI: 10.1254/jjp.32.1067. View

Zukin S, Young A, Snyder S . Gamma-aminobutyric acid binding to receptor sites in the rat central nervous system. Proc Natl Acad Sci U S A. 1974; 71(12):4802-7. PMC: 433985. DOI: 10.1073/pnas.71.12.4802. View

Tsuji M, Matsuoka Y, Nakajima T . Studies on formation of gamma-glutamylamines in rat brain and their synthetic and catabolic enzymes. J Neurochem. 1977; 29(4):633-8. DOI: 10.1111/j.1471-4159.1977.tb07779.x. View

Marnela K, Varga V, Dibo G, Lahdesmaki P . Position of the peptide linkage in glutamyl-taurine from calf brain synaptic vesicles. J Neurochem. 1987; 48(4):1090-2. DOI: 10.1111/j.1471-4159.1987.tb05631.x. View

Varga V, Torok K, Feuer L, Gulyas J, Somogyi J . gamma-Glutamyltransferase in the brain and its role in formation of gamma-L-glutamyl-taurine. Prog Clin Biol Res. 1985; 179:115-25. View

Kontro P, Oja S . Taurine uptake by rat brain synaptosomes. J Neurochem. 1978; 30(6):1297-304. DOI: 10.1111/j.1471-4159.1978.tb10459.x. View

Marnela K, Timonen M, Lahdesmaki P . Mass spectrometric analyses of brain synaptic peptides containing taurine. J Neurochem. 1984; 43(6):1650-3. DOI: 10.1111/j.1471-4159.1984.tb06091.x. View

Lahdesmaki P . Biosynthesis of taurine peptides in brain cytoplasmic fraction in vitro. Int J Neurosci. 1987; 37(1-2):79-84. DOI: 10.3109/00207458708991804. View

Larder A, McLennan H . Binding sites for L-glutamate in the central nervous system of the rat. Neurochem Res. 1984; 9(3):393-403. DOI: 10.1007/BF00963986. View

10.

Kontro P, Oja S . Taurine and GABA release from mouse cerebral cortex slices: potassium stimulation releases more taurine than GABA from developing brain. Brain Res. 1987; 465(1-2):277-91. DOI: 10.1016/0165-3806(87)90249-5. View

11.

Drejer J, Larsson O, Schousboe A . Characterization of uptake and release processes for D- and L-aspartate in primary cultures of astrocytes and cerebellar granule cells. Neurochem Res. 1983; 8(2):231-43. DOI: 10.1007/BF00963923. View

12.

Holopainen I, Enkvist M, Akerman K . Glutamate receptor agonists increase intracellular Ca2+ independently of voltage-gated Ca2+ channels in rat cerebellar granule cells. Neurosci Lett. 1989; 98(1):57-62. DOI: 10.1016/0304-3940(89)90373-x. View

13.

KUKORELLI T, Feuer L, Juhasz G, Detari L . Effect of glutaurine on sleep-wakefulness cycle and aggressive behaviour in the cat. Acta Physiol Hung. 1986; 67(1):31-5. View

14.

Varga V, Janaky R, Marnela K, Gulyas J, Kontro P, Oja S . Displacement of excitatory amino acid receptor ligands by acidic oligopeptides. Neurochem Res. 1989; 14(12):1223-7. DOI: 10.1007/BF00965513. View

15.

Feuer L, Fekete M, Kadar T, Telegdy G . Effect of intraventricular administration of glutaurine on norepinephrine, dopamine and serotonin turnover in different brain regions in rats. Acta Physiol Hung. 1983; 61(3):163-7. View

16.

Feuer L, ORMAI S . Radioprotective effect of a protein free parathyroid extract on the mitotic index of rat bone marrow cells. Experientia. 1979; 35(8):1091-2. DOI: 10.1007/BF01949961. View

17.

Abarca J, Bustos G . Release of d-[(3)H]aspartic acid from the rat substantia nigra: effect of veratridine-evoked depolarization and cortical ablation. Neurochem Int. 2010; 7(2):229-36. DOI: 10.1016/0197-0186(85)90109-3. View

18.

Garthwaite J, Garthwaite G . Cellular origins of cyclic GMP responses to excitatory amino acid receptor agonists in rat cerebellum in vitro. J Neurochem. 1987; 48(1):29-39. DOI: 10.1111/j.1471-4159.1987.tb13123.x. View

19.

Yoshida M, Karasawa N, Ito M, Sakai M, Nagatsu I . Demonstration of taurine-like immunoreactive structures in the rat brain. Neurosci Res. 1986; 3(4):356-63. DOI: 10.1016/0168-0102(86)90027-1. View

20.

Murphy D, Snowhill E, Williams M . Characterization of quisqualate recognition sites in rat brain tissue using DL-[3H]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and a filtration assay. Neurochem Res. 1987; 12(9):775-81. DOI: 10.1007/BF00971514. View