Antibodies Reacting with Cytoplasm of Subthalamic and Caudate Nuclei Neurons in Chorea and Acute Rheumatic Fever

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1976 Oct 1

PMID 789810

Citations 86

Authors

G Husby

I van de Rijn

J B Zabriskie

Z H Abdin

R C Williams Jr

Affiliations

Soon will be listed here.

Abstract

46% of sera from 30 children with rheumatic chorea showed IgG antibody reacting with neuronal cytoplasm of human caudate and subthalamic nuclei. The antibody was also detected in 14% of 50 children with active rheumatic carditis. 55 normal control sera, as well as 148 sera from a broad variety of other disease states showed a low prevalence (1.8-4.0%) of positive reactions. In rheumatic chorea the presence of anti-neuronal antibody appeared to correlate with severity and duration of clinical attacks. Antibody reacting with neuronal cytoplasm was completely removed by absorption with Group A streptococcal membranes or with isolated human neurons from caudate nucleus. Partial absorption of antibody was also recorded using Group A cell wall preparations but not with Group A carbohydrate. No absorption of positive reactions was seen with streptococcal Group D membranes or cell walls. In rheumatic chorea, anti-neuronal antibody appeared to represent cross-reaction with antigens shared by Group A streptococcal membranes.

Citing Articles

Autoantibodies in patients with obsessive-compulsive disorder: a systematic review.

Denzel D, Runge K, Feige B, Pankratz B, Pitsch K, Schlump A Transl Psychiatry. 2023; 13(1):241.

PMID: 37400462 PMC: 10318087. DOI: 10.1038/s41398-023-02545-9.

IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae of .

Kirvan C, Canini H, Swedo S, Hill H, Veasy G, Jankelow D Front Cardiovasc Med. 2023; 9:919700.

PMID: 36815140 PMC: 9939767. DOI: 10.3389/fcvm.2022.919700.

Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part II-Use of Immunomodulatory Therapies.

Frankovich J, Swedo S, Murphy T, Dale R, Agalliu D, Williams K J Child Adolesc Psychopharmacol. 2022; 27(7):574-593.

PMID: 36358107 PMC: 9836706. DOI: 10.1089/cap.2016.0148.

Tics and Emotions.

Leisman G, Sheldon D Brain Sci. 2022; 12(2).

PMID: 35204005 PMC: 8870550. DOI: 10.3390/brainsci12020242.

Sydenham's Chorea as the First Manifestation of Rheumatic Fever in Two Boys.

de Carvalho J, Churilov L Mediterr J Rheumatol. 2022; 32(4):369-372.

PMID: 35128332 PMC: 8802207. DOI: 10.31138/mjr.32.4.369.

References

Kaplan M, SVEC K . IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. III. PRESENCE IN HUMAN SERA OF STREPTOCOCCAL ANTIBODY CROSS-REACTIVE WITH HEART TISSUE. ASSOCIATION WITH STREPTOCOCCAL INFECTION, RHEUMATIC FEVER, AND GLOMERULONEPHRITIS. J Exp Med. 1964; 119:651-66. PMC: 2137853. DOI: 10.1084/jem.119.4.651. View

Markowitz A, LANGE Jr C . STREPTOCOCCAL RELATED GLOMERULONEPHRITIS. I. ISOLATION, IMMUNOCHEMISTRY AND COMPARATIVE CHEMISTRY OF SOLUBLE FRACTIONS FROM TYPE 12 NEPHRITOGENIC STREPTOCOCCI AND HUMAN GLOMERULI. J Immunol. 1964; 92:565-75. View

Kaplan M . IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. I. PROPERTIES OF AN ANTIGEN IN CERTAIN STRAINS OF GROUP A STREPTOCOCCI EXHIBITING AN IMMUNOLOGIC CROSS-REACTION WITH HUMAN HEART TISSUE. J Immunol. 1963; 90:595-606. View

Kingston D, GLYNN L . Anti-streptococcal antibodies reacting with brain tissue. I. Immunofluourescent studies. Br J Exp Pathol. 1976; 57(1):114-28. PMC: 2041178. View

Aminoff M, Trenchard A, Turner P, Wood W, Hills M . Plasma uptake of dopamine and 5-hydroxytryptamine and plasma-catecholamine levels in patients with Huntington's chorea. Lancet. 1974; 2(7889):1115-6. DOI: 10.1016/s0140-6736(74)90873-3. View

Zabriskie J, Hsu K, SEEGAL B . Heart-reactive antibody associated with rheumatic fever: characterization and diagnostic significance. Clin Exp Immunol. 1970; 7(2):147-59. PMC: 1712832. View

Sellinger O, Azcurra J, Johnson D, Ohlsson W, Lodin Z . Independence of protein synthesis and drug uptake in nerve cell bodies and glial cells isolated by a new technique. Nat New Biol. 1971; 230(16):253-6. DOI: 10.1038/newbio230253a0. View

Husby G, STRICKLAND R, Caldwell J, Williams Jr R . Localization of T and B cells and alpha fetoprotein in hepatic biopsies from patients with liver disease. J Clin Invest. 1975; 56(5):1198-1209. PMC: 301984. DOI: 10.1172/JCI108197. View

Husby G, Blomhoff J, Skrede S, Elgjo K, GJONE E . Detection of immunoglobulins in paraffin-embedded liver biopsies. Studies in 100 patients with special regard to immunological findings in active chronic hepatitis. Scand J Gastroenterol. 1973; 8(7):621-9. View

10.

Kawakita S, Iwamoto H . Studies on the pathogenesis of rheumatic heart disease. An immunological relationship between the polysaccharide of group A streptococcus and the glycoprotein of heart valve. Jpn Circ J. 1975; 39(4):439-46. DOI: 10.1253/jcj.39.439. View

11.

Vandvik B, Norrby E . Oligoclonal IgG antibody response in the central nervous system to different measles virus antigens in subacute sclerosing panencephalitis. Proc Natl Acad Sci U S A. 1973; 70(4):1060-3. PMC: 433425. DOI: 10.1073/pnas.70.4.1060. View

12.

Moskowitz M, Wurtman R . Catecholamines and neurologic diseases (first of two parts). N Engl J Med. 1975; 293(6):274-80. DOI: 10.1056/NEJM197508072930605. View

13.

Kingston D, GLYNN L . A cross-reaction between Str. pyogenes and human fibroblasts, endothelial cells and astrocytes. Immunology. 1971; 21(6):1003-16. PMC: 1408261. View

14.

Goldstein I, REBEYROTTE P, PARLEBAS J, Halpern B . Isolation from heart valves of glycopeptides which share immunological properties with Streptococcus haemolyticus group A polysaccharides. Nature. 1968; 219(5156):866-8. DOI: 10.1038/219866a0. View

15.

Fischetti V, Gotschlich E, BERNHEIMER A . Purification and physical properties of group C streptococcal phage-associated lysin. J Exp Med. 1971; 133(5):1105-17. PMC: 2138921. DOI: 10.1084/jem.133.5.1105. View

16.

Zabriskie J . Mimetic relationships between group A streptococci and mammalian tissues. Adv Immunol. 1967; 7:147-88. DOI: 10.1016/s0065-2776(08)60128-5. View

17.

Roy S . Proceedings: Epidemiological study of rheumatic fever and rheumatic heart disease in India. Jpn Circ J. 1975; 39(2):188-9. View

18.

Zabriskie J, FREIMER E . An immunological relationship between the group. A streptococcus and mammalian muscle. J Exp Med. 1966; 124(4):661-78. PMC: 2138256. DOI: 10.1084/jem.124.4.661. View