Budd-Chiari Syndrome and Epstein-Barr Virus (EBV) Associated Plasmacytoma in a Patient with Chronic Active EBV Infection

Overview

Journal Clin Investig

Specialty General Medicine

Date 1994 Nov 1

PMID 7894217

Citations 1

Authors

S Nagafuchi

H Ishibashi

K Anzai

K Ohshima

Y Ohno

N Fukushima

M Hashizume

K Sugimachi

H Chuman

M Kikuchi

Affiliations

Soon will be listed here.

Abstract

A 42-year-old Japanese man with chronic active Epstein-Barr virus (EBV) infection initially responded to treatment with interleukin-2 (IL-2). Six months later he developed thrombosis in the hepatic veins, and Budd-Chiari syndrome associated with severe hepatic damage was diagnosed. He also developed a solitary EBV-positive plasmacytoma in the right femur. Since these rare complications occurred after long-term IL-2 therapy, the possibility that long-term IL-2 therapy might cause Budd-Chiari syndrome and liver damage as well as EBV-associated plasmacytoma is discussed.

Citing Articles

Safety of low-dose subcutaneous recombinant interleukin-2: systematic review and meta-analysis of randomized controlled trials.

Mahmoudpour S, Jankowski M, Valerio L, Becker C, Espinola-Klein C, Konstantinides S Sci Rep. 2019; 9(1):7145.

PMID: 31073219 PMC: 6509335. DOI: 10.1038/s41598-019-43530-x.

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