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Effect of Indomethacin in Asthma: Evidence Against a Role for Prostaglandins in Its Pathogenesis

Overview
Journal Br J Clin Pharmacol
Specialty Pharmacology
Date 1975 Aug 1
PMID 788731
Citations 5
Authors
A P Smith
Affiliations
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Abstract

1. A clinical trial of the effects of indomethacin (200 mg daily) failed to show any objective evidence of improvement in six patients. 2. The same dose failed to inhibit exercise and antigen challenge induced bronchoconstriction, and this was considered to be evidence against the hypothesis that prostaglandins act as chemical mediatros in the pathogenesis of asthma.

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References
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Strandberg K, Hamberg M . Icreased excretion of 5alpha, 7alpha-dihydroxy-11-keto-tetranor-prostanoic acid on anaphylaxis in the guinea-pig. Prostaglandins. 1974; 6(2):159-70. DOI: 10.1016/0090-6980(74)90027-6. View
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Green K, Hedqvist P, SVANBORG N . Increased plasma levels of 15-keto-13,14-dihydro-prostaglandin F2X after allergen-provoked asthma in man. Lancet. 1974; 2(7894):1419-21. DOI: 10.1016/s0140-6736(74)90075-0. View