Zinc Ions Block the Intracellular Calcium Release Induced by Caffeine in Guinea-pig Taenia Caeci

Overview

Journal Experientia

Specialty Science

Date 1995 Feb 15

PMID 7875248

Citations 2

Authors

T Nasu

Affiliations

Soon will be listed here.

Abstract

Zn2+ in low concentrations (0.005-0.1 mM) inhibited the transient contractions in response to caffeine (25 mM) in a dose-dependent manner in smooth muscle of intact guinea-pig taenia caeci. At Zn2+ concentrations higher than 0.1 mM, caffeine did not elicit any response. After saponin-treatment of the fibres, which leaves the Ca2+ storage sites intact, caffeine contraction was completely inhibited by Zn2+ at a relatively low concentration (0.003 mM). However, in Triton-X-100-treated fibres, in which the Ca2+ release sites are destroyed, the contraction could be induced in the presence of Zn2+ by an increase in Ca2+. In conclusion, Zn2+ can block the intracellular Ca2+ release from caffeine-sensitive release sites in taenia caeci.

Citing Articles

Calcium's Role and Signaling in Aging Muscle, Cellular Senescence, and Mineral Interactions.

Terrell K, Choi S, Choi S Int J Mol Sci. 2023; 24(23).

PMID: 38069357 PMC: 10706910. DOI: 10.3390/ijms242317034.

Biphasic modulation of ryanodine binding to sarcoplasmic reticulum vesicles of skeletal muscle by Zn2+ ions.

Xia R, Cheng X, Wang H, Chen K, Wei Q, Zhang X Biochem J. 2000; 345 Pt 2:279-86.

PMID: 10620505 PMC: 1220757.

References

Somlyo A, Bond M, Somlyo A, Scarpa A . Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle. Proc Natl Acad Sci U S A. 1985; 82(15):5231-5. PMC: 390534. DOI: 10.1073/pnas.82.15.5231. View

PORTZEHL H, CALDWELL P, RUEEGG J . THE DEPENDENCE OF CONTRACTION AND RELAXATION OF MUSCLE FIBRES FROM THE CRAB MAIA SQUINADO ON THE INTERNAL CONCENTRATION OF FREE CALCIUM IONS. Biochim Biophys Acta. 1964; 79:581-91. DOI: 10.1016/0926-6577(64)90224-4. View

Iino M . Calcium-induced calcium release mechanism in guinea pig taenia caeci. J Gen Physiol. 1989; 94(2):363-83. PMC: 2228940. DOI: 10.1085/jgp.94.2.363. View

Bolton T, Lim S . Properties of calcium stores and transient outward currents in single smooth muscle cells of rabbit intestine. J Physiol. 1989; 409:385-401. PMC: 1190451. DOI: 10.1113/jphysiol.1989.sp017504. View

Mitsui M, Karaki H . Dual effects of carbachol on cytosolic Ca2+ and contraction in intestinal smooth muscle. Am J Physiol. 1990; 258(5 Pt 1):C787-93. DOI: 10.1152/ajpcell.1990.258.5.C787. View

Kobayashi S, Gong M, Somlyo A, Somlyo A . Ca2+ channel blockers distinguish between G protein-coupled pharmacomechanical Ca2+ release and Ca2+ sensitization. Am J Physiol. 1991; 260(2 Pt 1):C364-70. DOI: 10.1152/ajpcell.1991.260.2.C364. View

Noguera M, DOcon M . Different and common intracellular calcium-stores mobilized by noradrenaline and caffeine in vascular smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 1992; 345(3):333-41. DOI: 10.1007/BF00168695. View

Iino M, Kobayashi T, Endo M . Use of ryanodine for functional removal of the calcium store in smooth muscle cells of the guinea-pig. Biochem Biophys Res Commun. 1988; 152(1):417-22. DOI: 10.1016/s0006-291x(88)80730-7. View

Iino M . Calcium dependent inositol trisphosphate-induced calcium release in the guinea-pig taenia caeci. Biochem Biophys Res Commun. 1987; 142(1):47-52. DOI: 10.1016/0006-291x(87)90449-9. View

10.

Nasu T . Blockade by zinc ions of K(+)-induced contraction and calcium in guinea pig Taenia coli. Experientia. 1993; 49(10):865-9. DOI: 10.1007/BF01952599. View

11.

Nasu T . Zinc ions block the second but not the first phasic response to repetitive application of carbachol and histamine in guinea-pig taenia caeci. Experientia. 1994; 50(8):717-20. DOI: 10.1007/BF01919369. View

12.

Pacaud P, Bolton T . Relation between muscarinic receptor cationic current and internal calcium in guinea-pig jejunal smooth muscle cells. J Physiol. 1991; 441:477-99. PMC: 1180210. DOI: 10.1113/jphysiol.1991.sp018763. View

13.

Komori S, Bolton T . Calcium release induced by inositol 1,4,5-trisphosphate in single rabbit intestinal smooth muscle cells. J Physiol. 1991; 433:495-517. PMC: 1181385. DOI: 10.1113/jphysiol.1991.sp018440. View

14.

Sato K, Ozaki H, Karaki H . Multiple effects of caffeine on contraction and cytosolic free Ca2+ levels in vascular smooth muscle of rat aorta. Naunyn Schmiedebergs Arch Pharmacol. 1988; 338(4):443-8. DOI: 10.1007/BF00172125. View

15.

Chiu A, McCall D, Timmermans P . Pharmacological characteristics of receptor-operated and potential-operated Ca2+ channels in rat aorta. Eur J Pharmacol. 1986; 127(1-2):1-8. DOI: 10.1016/0014-2999(86)90199-8. View

16.

Ito K, Takakura S, Sato K, Sutko J . Ryanodine inhibits the release of calcium from intracellular stores in guinea pig aortic smooth muscle. Circ Res. 1986; 58(5):730-4. DOI: 10.1161/01.res.58.5.730. View