Effects of SR 48692, a Selective Non-peptide Neurotensin Receptor Antagonist, on Two Dopamine-dependent Behavioural Responses in Mice and Rats

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1994 Oct 1

PMID 7862953

Citations 3

Authors

M Poncelet

J Souilhac

C Gueudet

J.P. Terranova

D Gully

G Le Fur

P Soubrie

Affiliations

Soon will be listed here.

Abstract

One major mechanism underlying the central action of neurotensin is an interaction with the function of dopamine (DA)-containing neurons. In addition, direct or indirect DA agonists have been reported to promote neurotensin release. We have found that SR 48692, a non-peptide neurotensin receptor antagonist (0.04-0.64 mg/kg orally), antagonizes (50-65%) yawning induced by apomorphine (0.07 mg/kg SC) or bromocriptine (2 mg/kg IP) in rats, and turning behaviour induced by intrastriatal injection of apomorphine (0.25 micrograms), (+) SKF 38393 (0.1 micrograms), bromocriptine (0.01 ng) or (+) amphetamine (10 micrograms) in mice. Other apomorphine-induced effects in mice and rats such as climbing, hypothermia, hypo- and hyper-locomotion, penile erections and stereotypies were not significantly modified by SR 48692. Taken together, these data suggest that neurotensin may play a permissive role in the expression of some but not all behavioural responses to DA receptor stimulation.

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References

Merchant K, BUSH L, GIBB J, Hanson G . Neurotensin-dopamine interactions in the substantia nigra of the rat brain. J Pharmacol Exp Ther. 1990; 255(2):775-80. View

Rivest R, Jolicoeur F, Marsden C . Neurotensin causes a greater increase in the metabolism of dopamine in the accumbens than in the striatum in vivo. Neuropharmacology. 1991; 30(1):25-33. DOI: 10.1016/0028-3908(91)90038-d. View

Poncelet M, Gueudet C, Gully D, Soubrie P, Le Fur G . Turning behavior induced by intrastriatal injection of neurotensin in mice: sensitivity to non-peptide neurotensin antagonists. Naunyn Schmiedebergs Arch Pharmacol. 1994; 349(1):57-60. DOI: 10.1007/BF00178206. View

Zarrindast M, Jamshidzadeh A . Inhibitory effect of morphine on yawning induced by cholinoceptor and dopamine D2 receptor activation in rats. Br J Pharmacol. 1992; 105(3):675-8. PMC: 1908467. DOI: 10.1111/j.1476-5381.1992.tb09037.x. View

Nouel D, Costentin J . Inhibition of apomorphine-induced yawning and penile erection by neurotensin. Peptides. 1991; 12(4):755-9. DOI: 10.1016/0196-9781(91)90129-d. View

Morelli M, Longoni R, Spina L, Di Chiara G . Antagonism of apomorphine-induced yawning by SCH 23390: evidence against the autoreceptor hypothesis. Psychopharmacology (Berl). 1986; 89(2):259-60. DOI: 10.1007/BF00310640. View

Poncelet M, Santucci V, Paul R, Gueudet C, Lavastre S, Guitard J . Neuropharmacological profile of a novel and selective ligand of the sigma site: SR 31742A. Neuropharmacology. 1993; 32(6):605-15. DOI: 10.1016/0028-3908(93)90057-a. View

Gully D, Canton M, Boigegrain R, Jeanjean F, Molimard J, Poncelet M . Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor. Proc Natl Acad Sci U S A. 1993; 90(1):65-9. PMC: 45600. DOI: 10.1073/pnas.90.1.65. View

Tanganelli S, von Euler G, Fuxe K, Agnati L, Ungerstedt U . Neurotensin counteracts apomorphine-induced inhibition of dopamine release as studied by microdialysis in rat neostriatum. Brain Res. 1989; 502(2):319-24. DOI: 10.1016/0006-8993(89)90627-6. View

10.

Bean A, During M, Roth R . Effects of dopamine autoreceptor stimulation on the release of colocalized transmitters: in vivo release of dopamine and neurotensin from rat prefrontal cortex. Neurosci Lett. 1990; 108(1-2):143-8. DOI: 10.1016/0304-3940(90)90721-k. View

11.

Singh N, BUSH L, GIBB J, Hanson G . Dopamine-mediated changes in central nervous system neurotensin systems: a role for NMDA receptors. Eur J Pharmacol. 1990; 187(3):337-44. DOI: 10.1016/0014-2999(90)90361-9. View

12.

Stoessl A, Dourish C, Iversen S . Apomorphine-induced yawning in rats is abolished by bilateral 6-hydroxydopamine lesions of the substantia nigra. Psychopharmacology (Berl). 1987; 93(3):336-42. DOI: 10.1007/BF00187253. View

13.

Seutin V, Massotte L, Dresse A . Electrophysiological effects of neurotensin on dopaminergic neurones of the ventral tegmental area of the rat in vitro. Neuropharmacology. 1989; 28(9):949-54. DOI: 10.1016/0028-3908(89)90194-9. View

14.

Dourish C, Hutson P . Bilateral lesions of the striatum induced with 6-hydroxydopamine abolish apomorphine-induced yawning in rats. Neuropharmacology. 1985; 24(11):1051-5. DOI: 10.1016/0028-3908(85)90190-x. View

15.

Kalivas P . Neurotransmitter regulation of dopamine neurons in the ventral tegmental area. Brain Res Brain Res Rev. 1993; 18(1):75-113. DOI: 10.1016/0165-0173(93)90008-n. View

16.

Puech A, Simon P, BOISSIER J . Benzamides and classical neuroleptics: comparison of their actions using 6 apomorphine-induced effects. Eur J Pharmacol. 1978; 50(4):291-300. DOI: 10.1016/0014-2999(78)90134-6. View

17.

Fuxe K, OConnor W, Antonelli T, Osborne P, Tanganelli S, Agnati L . Evidence for a substrate of neuronal plasticity based on pre- and postsynaptic neurotensin-dopamine receptor interactions in the neostriatum. Proc Natl Acad Sci U S A. 1992; 89(12):5591-5. PMC: 49338. DOI: 10.1073/pnas.89.12.5591. View

18.

Sanz B, Exposito I, Mora F . Effects of neurotensin on the release of glutamic acid in the prefrontal cortex and striatum of the rat. Neuroreport. 1993; 4(10):1194-6. View

19.

During M, Bean A, Roth R . Effects of CNS stimulants on the in vivo release of the colocalized transmitters, dopamine and neurotensin, from rat prefrontal cortex. Neurosci Lett. 1992; 140(1):129-33. DOI: 10.1016/0304-3940(92)90698-7. View

20.

Nemeroff C, Luttinger D, Hernandez D, Mailman R, Mason G, Davis S . Interactions of neurotensin with brain dopamine systems: biochemical and behavioral studies. J Pharmacol Exp Ther. 1983; 225(2):337-45. View