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Effect of Switching Carbamazepine to Oxcarbazepine on the Plasma Levels of Neuroleptics. A Case Report

Overview
Journal Psychopharmacology (Berl)
Specialty Pharmacology
Date 1994 Sep 1
PMID 7862923
Citations 9
Authors
V Raitasuo
R LEHTOVAARA
M O Huttunen
Affiliations
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Abstract

Carbamazepine was switched to its 10-keto analogue oxcarbazepine among six difficult-to-treat schizophrenic or organic psychotic patients using concomitantly haloperidol, chlorpromazine or clozapine. This change resulted within 2-4 weeks in the 50-200% increase in the plasma levels of these neuroleptics and the appearance of extrapyramidal symptoms. None of the patients showed any clinical deteriotation during the following 3-6 months. The results of this case report support the idea that in contrast with carbamazepine oxcarbazepine does not induce the hepatic microsomal enzyme systems regulating the inactivation of antipsychotic drugs.

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