The Effect of Adenosine on Cochlear Potentials in the Guinea Pig

Overview

Journal Eur Arch Otorhinolaryngol

Specialty Otorhinolaryngology

Date 1994 Jan 1

PMID 7857632

Citations 2

Authors

K Nario

I Kitano

N Mori

T Matsunaga

Affiliations

Soon will be listed here.

Abstract

The effect of adenosine on cochlear potentials was examined in the guinea pig. Perilymphatic perfusion with 10(-4) M adenosine produced a significant decrease in the amplitudes of cochlear microphonics, negative summating potential (-SP) and compound action potential (CAP) and significant prolongation of N1 latency with no change in the endocochlear potential. The decreases in the amplitudes of -SP and CAP caused by adenosine were dose-dependent. Perilymphatic perfusion with an inactive analogue, 8-bromoadenosine, produced no changes in the cochlear potentials. The A1-receptor agonist, 2-chloro-adenosine, produced a similar change in cochlear potentials to adenosine, while no changes were produced by the A2-receptor agonist, 5'-(N-ethylcarboxamido)-adenosine. These results suggest that adenosine may have a modulatory function through an A1 receptor in the cochlea.

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References

Haas H, Greene R . Endogenous adenosine inhibits hippocampal CA1 neurones: further evidence from extra- and intracellular recording. Naunyn Schmiedebergs Arch Pharmacol. 1988; 337(5):561-5. DOI: 10.1007/BF00182732. View

Jackisch R, Fehr R, Hertting G . Adenosine: an endogenous modulator of hippocampal noradrenaline release. Neuropharmacology. 1985; 24(6):499-507. DOI: 10.1016/0028-3908(85)90055-3. View

Burnstock G . Review lecture. Neurotransmitters and trophic factors in the autonomic nervous system. J Physiol. 1981; 313:1-35. PMC: 1274434. DOI: 10.1113/jphysiol.1981.sp013648. View

Phillis J, Wu P . The role of adenosine and its nucleotides in central synaptic transmission. Prog Neurobiol. 1981; 16(3-4):187-239. DOI: 10.1016/0301-0082(81)90014-9. View

Paton D, Taerum T . A comparison of P1- and P2-purinoceptors. Ann N Y Acad Sci. 1990; 603:165-71. DOI: 10.1111/j.1749-6632.1990.tb37670.x. View

Kuroda Y . Physiological roles of adenosine derivatives which are released during neurotransmission in mammalian brain. J Physiol (Paris). 1978; 74(5):463-70. View

Proctor W, Dunwiddie T . Pre- and postsynaptic actions of adenosine in the in vitro rat hippocampus. Brain Res. 1987; 426(1):187-90. DOI: 10.1016/0006-8993(87)90441-0. View

Phillis J, Edstrom J, Kostopoulos G, Kirkpatrick J . Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex. Can J Physiol Pharmacol. 1979; 57(11):1289-312. DOI: 10.1139/y79-194. View

Bryant G, Barron S, Norris C, GUTH P . Adenosine is a modulator of hair cell-afferent neurotransmission. Hear Res. 1987; 30(2-3):231-7. DOI: 10.1016/0378-5955(87)90139-0. View

10.

Dolphin A, Archer E . An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus. Neurosci Lett. 1983; 43(1):49-54. DOI: 10.1016/0304-3940(83)90127-1. View

11.

Bruns R . Adenosine receptors. Roles and pharmacology. Ann N Y Acad Sci. 1990; 603:211-25; discussion 225-6. DOI: 10.1111/j.1749-6632.1990.tb37674.x. View

12.

Pedata F, Antonelli T, Lambertini L, Beani L, Pepeu G . Effect of adenosine, adenosine triphosphate, adenosine deaminase, dipyridamole and aminophylline on acetylcholine release from electrically-stimulated brain slices. Neuropharmacology. 1983; 22(5):609-14. DOI: 10.1016/0028-3908(83)90152-1. View

13.

Dunwiddie T . The physiological role of adenosine in the central nervous system. Int Rev Neurobiol. 1985; 27:63-139. DOI: 10.1016/s0074-7742(08)60556-5. View

14.

Corradetti R, Lo Conte G, Moroni F, Passani M, Pepeu G . Adenosine decreases aspartate and glutamate release from rat hippocampal slices. Eur J Pharmacol. 1984; 104(1-2):19-26. DOI: 10.1016/0014-2999(84)90364-9. View

15.

Collins G, Anson J . Adenosine A1 receptors mediate the inhibitory effects of exogenous adenosine in the rat olfactory cortex slice. Neuropharmacology. 1985; 24(11):1077-84. DOI: 10.1016/0028-3908(85)90195-9. View

16.

Bobbin R, Jastreboff P, Fallon M, Littman T . Nimodipine, an L-channel Ca2+ antagonist, reverses the negative summating potential recorded from the guinea pig cochlea. Hear Res. 1990; 46(3):277-87. DOI: 10.1016/0378-5955(90)90009-e. View

17.

Schubert P, Heinemann U, Kolb R . Differential effect of adenosine on pre- and postsynaptic calcium fluxes. Brain Res. 1986; 376(2):382-6. DOI: 10.1016/0006-8993(86)90204-0. View

18.

Jackisch R, Strittmatter H, Kasakov L, Hertting G . Endogenous adenosine as a modulator of hippocampal acetylcholine release. Naunyn Schmiedebergs Arch Pharmacol. 1984; 327(4):319-25. DOI: 10.1007/BF00506243. View

19.

Alzheimer C, Kargl L, Ten Bruggencate G . Adenosinergic inhibition in hippocampus is mediated by adenosine A1 receptors very similar to those of peripheral tissues. Eur J Pharmacol. 1991; 196(3):313-7. DOI: 10.1016/0014-2999(91)90445-v. View

20.

Stone T . Physiological roles for adenosine and adenosine 5'-triphosphate in the nervous system. Neuroscience. 1981; 6(4):523-55. DOI: 10.1016/0306-4522(81)90145-7. View