Erythropoietin Cell Biology

Erythropoietin (EPO) mediates its biologic actions in responsive cells through the 78 kDa cell surface form of the EPO receptor. The biosynthesis, activations, and destruction of EPO receptors are described. The binding of EPO to its receptor leads to the activation of a tyrosine protein kinase(s) that results in the phosphorylation of the receptor and other proteins.