Ibotenic Acid Lesions of the Striatum Reduce Drug-induced Rotation in the 6-hydroxydopamine-lesioned Rat

Overview

Journal Exp Brain Res

Specialty Neurology

Date 1994 Jan 1

PMID 7851507

Citations 5

Authors

R Barker

S B Dunnett

Affiliations

Soon will be listed here.

Abstract

Lesions of the dopaminergic nigrostriatal tract produce a range of motor and sensorimotor deficits. One of the simplest and most reliable is the rotational response of the animal following activation with drugs that stimulate the dopaminergic network, most notably amphetamine and apomorphine. Consequently, the rotation test has been extensively used in assessing the success of treatments designed to restore dopaminergic function, including neural transplants. The present study investigates whether rotation induced by 6-hydroxydopamine lesions of the nigrostriatal bundle in rats is modified by additional lesions in the neostriatum. It was found that apomorphine-induced rotation can be reduced by ibotenic acid lesions of the dopamine-deafferented striatum, and that the extent of the reduction was proportional to the size of the lesions. In contrast, such lesions produced a non-significant reduction in amphetamine-induced rotation, although the correlation between the extent of the reduction and the size of the lesion was again apparent. Since the pattern of change was similar in direction, albeit smaller in magnitude, than the previously reported effects of intrastriatal transplantation in rats with similar nigrostriatal lesions, rotation tests alone do not provide an unequivocal test of graft survival and function.

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References

Freed W, Perlow M, Karoum F, Seiger A, Olson L, Hoffer B . Restoration of dopaminergic function by grafting of fetal rat substantia nigra to the caudate nucleus: long-term behavioral, biochemical, and histochemical studies. Ann Neurol. 1980; 8(5):510-9. DOI: 10.1002/ana.410080508. View

Norman A, Norgren R, Wyatt L, Hildebrand J, Sanberg P . The direction of apomorphine-induced rotation behavior is dependent on the location of excitotoxin lesions in the rat basal ganglia. Brain Res. 1992; 569(1):169-72. DOI: 10.1016/0006-8993(92)90386-n. View

Kamo H, Kim S, McGeer P, Shin D . Functional recovery in a rat model of Parkinson's disease following transplantation of cultured human sympathetic neurons. Brain Res. 1986; 397(2):372-6. DOI: 10.1016/0006-8993(86)90641-4. View

Paul M, Graybiel A, David J, Robertson H . D1-like and D2-like dopamine receptors synergistically activate rotation and c-fos expression in the dopamine-depleted striatum in a rat model of Parkinson's disease. J Neurosci. 1992; 12(10):3729-42. PMC: 6575976. View

Wolf M, White F, Nassar R, Brooderson R, Khansa M . Differential development of autoreceptor subsensitivity and enhanced dopamine release during amphetamine sensitization. J Pharmacol Exp Ther. 1993; 264(1):249-55. View

Dunnett S, Hernandez T, Summerfield A, Jones G, Arbuthnott G . Graft-derived recovery from 6-OHDA lesions: specificity of ventral mesencephalic graft tissues. Exp Brain Res. 1988; 71(2):411-24. DOI: 10.1007/BF00247501. View

Zigmond M, Stricker E . Animal models of parkinsonism using selective neurotoxins: clinical and basic implications. Int Rev Neurobiol. 1989; 31:1-79. DOI: 10.1016/s0074-7742(08)60277-9. View

Zetterstrom T, Brundin P, Gage F, Sharp T, Isacson O, Dunnett S . In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis. Brain Res. 1986; 362(2):344-9. DOI: 10.1016/0006-8993(86)90460-9. View

Pezzoli G, Fahn S, Dwork A, Truong D, de Yebenes J, Jackson-Lewis V . Non-chromaffin tissue plus nerve growth factor reduces experimental parkinsonism in aged rats. Brain Res. 1988; 459(2):398-403. DOI: 10.1016/0006-8993(88)90659-2. View

10.

KOELLE G . The histochemical identification of acetylcholinesterase in cholinergic, adrenergic and sensory neurons. J Pharmacol Exp Ther. 1955; 114(2):167-84. View

11.

Pycock C, Marsden C . The rotating rodent: a two component system?. Eur J Pharmacol. 1978; 47(2):167-75. DOI: 10.1016/0014-2999(78)90388-6. View

12.

Koshikawa N, Mori E, Maruyama Y, Yatsushige N, Kobayashi M . Role of dopamine D-1 and D-2 receptors in the ventral striatum in the turning behaviour of rats. Eur J Pharmacol. 1990; 178(2):233-7. DOI: 10.1016/0014-2999(90)90480-t. View

13.

Dunnett S . Transplantation of embryonic dopamine neurons: what we know from rats. J Neurol. 1991; 238(2):65-74. DOI: 10.1007/BF00315683. View

14.

Ungerstedt U . Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour. Acta Physiol Scand Suppl. 1971; 367:49-68. DOI: 10.1111/j.1365-201x.1971.tb10999.x. View

15.

PLUNKETT R, Bankiewicz K, Cummins A, Miletich R, Schwartz J, Oldfield E . Long-term evaluation of hemiparkinsonian monkeys after adrenal autografting or cavitation alone. J Neurosurg. 1990; 73(6):918-26. DOI: 10.3171/jns.1990.73.6.0918. View

16.

Riopelle R . Adrenal medulla autografts in Parkinson's disease: a proposed mechanism of action. Can J Neurol Sci. 1988; 15(4):366-70. View

17.

Schwarcz R, Fuxe K, Agnati L, Hokfelt T, Coyle J . Rotational behaviour in rats with unilateral striatal kainic acid lesions: a behavioural model for studies on intact dopamine receptors. Brain Res. 1979; 170(3):485-95. DOI: 10.1016/0006-8993(79)90966-1. View

18.

Narang N, HUNT M, Pundt L, Alburges M, Wamsley J . Unilateral ibotenic acid lesion of the caudate putamen results in D2 receptor alterations on the contralateral side. Exp Neurol. 1993; 121(1):40-7. DOI: 10.1006/exnr.1993.1069. View

19.

Kuczenski R, Segal D . Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis. J Neurosci. 1989; 9(6):2051-65. PMC: 6569745. View

20.

Loughlin S, Fallon J . Mesostriatal projections from ventral tegmentum and dorsal raphe: cells project ipsilaterally or contralaterally but not bilaterally. Neurosci Lett. 1982; 32(1):11-6. DOI: 10.1016/0304-3940(82)90221-x. View