Clinical Applicability of Human in Vivo Localized Phosphorus-31 Magnetic Resonance Spectroscopy of Bone and Soft Tissue Tumors

Overview

Journal Ann Surg Oncol

Publisher Springer

Specialty Oncology

Date 1994 Nov 1

PMID 7850556

Citations 1

Authors

H J Hoekstra

W J Boeve

R L Kamman

E L Mooyaart

Affiliations

Soon will be listed here.

Abstract

Background: Magnetic resonance imaging (MRI) is of restricted value for the in vivo characterization of tumor types. The applicability of phosphorus-31 (31P) magnetic resonance spectroscopy (MRS) in the diagnosis of bone and soft tissue tumors is unknown.

Methods: A total of 191 consecutive patients (85 females and 106 males; mean age 41 years, range 1-80) with a well-defined bone or soft tissue tumor on MRI were analyzed for additional 31P spectroscopy. Histology and/or cytology was obtained from all tumors. Because of low sensitivity of the 31P nucleus and the contamination of surrounding tissue, only large, superficially located tumors accessible to the surface coil could be accepted for MRS.

Results: Twenty-one patients (11%) could be included in the study. From this remaining group only 12 studies (57%) produced spectra with well resolved phosphorus peaks and an acceptable signal-to-noise ratio. However, these spectra did not allow differentiation between the benign and malignant nature of the lesions. The other 9 studies showed spectra with poor signal intensities and/or poorly defined peaks, making tumor differentiation impossible.

Conclusion: Only 6% of the bone and soft tissue tumors produced well defined spectra, which implies that localized 31P MRS cannot be considered as a routine technique in the diagnostic and treatment evaluation of bone and soft tissue tumors.

Citing Articles

Assessing prognosis for high-grade soft-tissue sarcomas: search for a marker.

Li X, Parkekh S, Rosenberg A, Mankin H Ann Surg Oncol. 1996; 3(6):550-7.

PMID: 8915487 DOI: 10.1007/BF02306088.

References

McKenna W, Lenkinski R, Hendrix R, Vogele K, Bloch P . The use of magnetic resonance imaging and spectroscopy in the assessment of patients with head and neck and other superficial human malignancies. Cancer. 1989; 64(10):2069-75. DOI: 10.1002/1097-0142(19891115)64:10<2069::aid-cncr2820641017>3.0.co;2-s. View

Just M, Gutjahr P, Juretschke H, Dittrich M, Higer H, Klose K . [31-phosphorus spectroscopy of osteogenic sarcoma. Possibilities in therapy control in comparison with imaging methods]. Rofo. 1987; 146(2):144-8. DOI: 10.1055/s-2008-1048460. View

Oberhaensli R, Hilton-Jones D, Bore P, Hands L, Rampling R, Radda G . Biochemical investigation of human tumours in vivo with phosphorus-31 magnetic resonance spectroscopy. Lancet. 1986; 2(8497):8-11. DOI: 10.1016/s0140-6736(86)92558-4. View

Karczmar G, Meyerhoff D, Boska M, Hubesch B, Poole J, Matson G . P-31 spectroscopy study of response of superficial human tumors to therapy. Radiology. 1991; 179(1):149-53. DOI: 10.1148/radiology.179.1.2006266. View

Zlatkin M, Lenkinski R, Shinkwin M, Schmidt R, Daly J, Holland G . Combined MR imaging and spectroscopy of bone and soft tissue tumors. J Comput Assist Tomogr. 1990; 14(1):1-10. DOI: 10.1097/00004728-199001000-00001. View

Ross B, Helsper J, Cox I, Young I, Kempf R, Makepeace A . Osteosarcoma and other neoplasms of bone. Magnetic resonance spectroscopy to monitor therapy. Arch Surg. 1987; 122(12):1464-9. DOI: 10.1001/archsurg.1987.01400240112021. View

Lenkinski R, Listerud J, Shinkwin M, Zlatkin M, Kressel H, Schmidt R . Magnetic resonance imaging and magnetic resonance spectroscopy of bone tumors and bone marrow disease. Invest Radiol. 1989; 24(12):1006-10. DOI: 10.1097/00004424-198912000-00019. View

Demas B, Heelan R, Lane J, Marcove R, Hajdu S, Brennan M . Soft-tissue sarcomas of the extremities: comparison of MR and CT in determining the extent of disease. AJR Am J Roentgenol. 1988; 150(3):615-20. DOI: 10.2214/ajr.150.3.615. View

Griffiths J, Cady E, EDWARDS R, McCready V, WILKIE D, Wiltshaw E . 31P-NMR studies of a human tumour in situ. Lancet. 1983; 1(8339):1435-6. DOI: 10.1016/s0140-6736(83)92375-9. View

10.

Negendank W, Brown T, Evelhoch J, Griffiths J, Liotta L, Margulis A . Proceedings of a National Cancer Institute workshop: MR spectroscopy and tumor cell biology. Radiology. 1992; 185(3):875-83. DOI: 10.1148/radiology.185.3.1438779. View

11.

Semmler W, Gademann G, Zabel H, Lorenz W, van Kaick G . Monitoring human tumor response to therapy by means of P-31 MR spectroscopy. Radiology. 1988; 166(2):533-9. DOI: 10.1148/radiology.166.2.3336731. View

12.

Sundaram M, McGuire M, Herbold D . Magnetic resonance imaging of soft tissue masses: an evaluation of fifty-three histologically proven tumors. Magn Reson Imaging. 1988; 6(3):237-48. DOI: 10.1016/0730-725x(88)90397-9. View

13.

Aisen A, MARTEL W, Braunstein E, McMillin K, Phillips W, Kling T . MRI and CT evaluation of primary bone and soft-tissue tumors. AJR Am J Roentgenol. 1986; 146(4):749-56. DOI: 10.2214/ajr.146.4.749. View

14.

STOKER D . Management of bone tumours--the radiologist's role. Clin Radiol. 1989; 40(3):233-9. DOI: 10.1016/s0009-9260(89)80179-5. View

15.

Hogeboom W, Hoekstra H, Mooyaart E, Sleijfer D, Freling N, Willemse P . The role of magnetic resonance imaging and computed tomography in the treatment evaluation of retroperitoneal lymph-node metastases of non-seminomatous testicular tumors. Eur J Radiol. 1991; 13(1):31-6. DOI: 10.1016/0720-048x(91)90052-w. View

16.

Bloem J, Taminiau A, Eulderink F, Hermans J, Pauwels E . Radiologic staging of primary bone sarcoma: MR imaging, scintigraphy, angiography, and CT correlated with pathologic examination. Radiology. 1988; 169(3):805-10. DOI: 10.1148/radiology.169.3.3055041. View

17.

Kransdorf M, Jelinek J, Moser Jr R, Utz J, Brower A, Hudson T . Soft-tissue masses: diagnosis using MR imaging. AJR Am J Roentgenol. 1989; 153(3):541-7. DOI: 10.2214/ajr.153.3.541. View

18.

Majors A, Ng T, Xue M, MEANEY T . Monitoring therapeutic response of human superficial tumors using phase-encoded spectroscopy. Magn Reson Med. 1989; 12(3):369-78. DOI: 10.1002/mrm.1910120309. View

19.

Hogeboom W, Hoekstra H, Mooyaart E, Freling N, Veth R, Postma A . MRI or CT in the preoperative diagnosis of bone tumours. Eur J Surg Oncol. 1992; 18(1):67-72. View

20.

Ehman R, Berquist T, Mcleod R . MR imaging of the musculoskeletal system: a 5-year appraisal. Radiology. 1988; 166(2):313-20. DOI: 10.1148/radiology.166.2.3275975. View