Physiological and Pathological Changes in Tissue Monoamine Oxidase Activity

Overview

Journal J Neural Transm

Specialties Neurology
Physiology

Date 1976 Jan 1

PMID 784909

Citations 5

Authors

M B Youdim

M Holzbauer

Affiliations

Soon will be listed here.

Abstract

This article explores the possibility that malfunction of the enzyme monoamine oxidase (E.C. 1.4.3.4., MAO) could lead to aberrations in the catabolism of biogenic amines in the central nervous system and give rise to certain mental abnormalities. No conclusive evidence could be presented to substantiate this. Data on the normal function of the enyzme (for example its existence in multiple forms, the control of MAO activity by hormones or the independent development of MAO activities towards different substrates during maturation) are reviewed.

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Activity of catechol-o-methyltransferase in brain regions and adrenal gland during the oestrus cycle.

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Comparative effects of hypophysectomy and adrenalectomy upon plasma and adrenal monoamines in pregnant and non-pregnant rats.

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The metabolism of 5-hydroxytryptamine and beta-phenylethylamine in perfused rat lung and in vitro.

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