HIV-2-infected Patients Survive Longer Than HIV-1-infected Patients

Overview

Journal AIDS

Specialty Infectious Diseases

Date 1994 Nov 1

PMID 7848600

Citations 37

Authors

H Whittle

J Morris

J Todd

T Corrah

S Sabally

J Bangali

P T NGom

M Rolfe

A Wilkins

Affiliations

Soon will be listed here.

Abstract

Objective: To compare survival of patients infected with HIV-1 and HIV-2.

Design: Longitudinal follow-up of 175 HIV-1- and 294 HIV-2-infected patients identified in, or referred to a hospital in The Gambia.

Methods: Survival analysis methods were used and the death rate ratios for HIV-2 relative to HIV-1 patients were estimated using proportional hazard regression models that allowed for age, sex and clinical or immunological features.

Results: The overall death rate ratio for HIV-2 relative to HIV-1 was 0.67 [95% confidence interval (CI), 0.49-0.91] when adjusted for age, sex and World Health Organization Bangui clinical classification. When allowing for age, sex and three strata of CD4+ count, the rate ratio was 0.64 (95% CI, 0.43-0.94), and for three strata of beta 2-microglobulin levels 0.60 (95% CI, 0.42-0.84).

Conclusion: Mortality rate in HIV-2-infected patients is approximately two-thirds of that for HIV-1-infected patients.

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