Release of TNF Alpha and IL6 from Human Monocytes Infected with Mycobacterium Kansasii: a Comparison to Mycobacterium Avium

Overview

Journal Infection

Date 1994 Sep 1

PMID 7843810

Citations 1

Authors

F Stauffer

E P Petrow

H Burgmann

W Graninger

A Georgopoulos

Affiliations

Soon will be listed here.

Abstract

Tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL6) are cytokines with a varied spectrum of inflammatory and immunological activities, for example modulation of acute phase proteins, fever and stimulation of B-lymphocytes. Mycobacterium avium has been shown to stimulate the release of TNF alpha and IL6 from cultured human monocytes and macrophages into the cell supernatant. Cultured human monocytes were infected with Mycobacterium kansasii and M. avium. The concentrations of TNF alpha and IL6 were measured in the supernatant. Monocytes infected with M. kansasii produced significantly lower amounts of TNF alpha (34.8 +/- 20.3 pg/ml) and IL6 (12.0 +/- 8.9 pg/ml) compared to monocytes infected with M. avium (198.3 +/- 171.7 pg/ml and 63.2 +/- 37.6 pg/ml respectively). The extent of cytokine production might be relevant for the clinical manifestation of mycobacterial disease.

Citing Articles

The rLrp of Mycobacterium tuberculosis inhibits proinflammatory cytokine production and downregulates APC function in mouse macrophages via a TLR2-mediated PI3K/Akt pathway activation-dependent mechanism.

Liu Y, Li J, Chen S, Huang H, Cai H Cell Mol Immunol. 2015; 13(6):729-746.

PMID: 26166760 PMC: 5101441. DOI: 10.1038/cmi.2015.58.

References

Blanchard D, Pearson C, Djeu J . Differential release of interleukin (IL)-1 alpha, IL-1 beta, and IL-6 from normal human monocytes stimulated with a virulent and an avirulent isogenic variant of Mycobacterium avium-intracellulare complex. J Infect Dis. 1992; 165(4):702-9. DOI: 10.1093/infdis/165.4.702. View

Good R, Snider Jr D . Isolation of nontuberculous mycobacteria in the United States, 1980. J Infect Dis. 1982; 146(6):829-33. DOI: 10.1093/infdis/146.6.829. View

Yamamoto M, Ogura Y, Sudo K, Hibino S . Diagnostic criteria for disease caused by atypical mycobacteria. Am Rev Respir Dis. 1967; 96(4):773-8. DOI: 10.1164/arrd.1967.96.4.773. View

Hirasuna J . Disseminated Mycobacterium kansasii infection in the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1987; 107(5):784. DOI: 10.7326/0003-4819-107-5-784_1. View

Contreras M, Cheung O, Sanders D, Goldstein R . Pulmonary infection with nontuberculous mycobacteria. Am Rev Respir Dis. 1988; 137(1):149-52. DOI: 10.1164/ajrccm/137.1.149. View

Tsukamura M, SHIMOIDE H, Kita N, Kawakami K, Ito T, Nakajima N . Epidemiologic studies of lung disease due to mycobacteria other than Mycobacterium tuberculosis in Japan. Rev Infect Dis. 1981; 3(5):997-1007. DOI: 10.1093/clinids/3.5.997. View

Denis M . Interleukin-6 is used as a growth factor by virulent Mycobacterium avium: presence of specific receptors. Cell Immunol. 1992; 141(1):182-8. DOI: 10.1016/0008-8749(92)90137-e. View

Minkin B, Mills C, Bullock D, Burke F . Mycobacterium kansasii osteomyelitis of the scaphoid. J Hand Surg Am. 1987; 12(6):1092-4. DOI: 10.1016/s0363-5023(87)80121-1. View

Dinarello C . Interleukin-1 and its biologically related cytokines. Adv Immunol. 1989; 44:153-205. DOI: 10.1016/s0065-2776(08)60642-2. View

10.

Sutker W, LANKFORD L, TOMPSETT R . Granulomatous synovitis: the role of atypical mycobacteria. Rev Infect Dis. 1979; 1(5):729-35. DOI: 10.1093/clinids/1.5.729. View

11.

BUHLER V, Pollak A . Human infection with atypical acid-fast organisms; report of two cases with pathologic findings. Am J Clin Pathol. 1953; 23(4):363-74. DOI: 10.1093/ajcp/23.4.363. View

12.

Lai K, Stottmeier K, Sherman I, McCabe W . Mycobacterial cervical lymphadenopathy. Relation of etiologic agents to age. JAMA. 1984; 251(10):1286-8. DOI: 10.1001/jama.251.10.1286. View

13.

Bermudez L, Young L . Tumor necrosis factor, alone or in combination with IL-2, but not IFN-gamma, is associated with macrophage killing of Mycobacterium avium complex. J Immunol. 1988; 140(9):3006-13. View

14.

Mackaness G . Cellular resistance to infection. J Exp Med. 1962; 116:381-406. PMC: 2137547. DOI: 10.1084/jem.116.3.381. View

15.

Tsukamura M, Kita N, SHIMOIDE H, Arakawa H, KUZE A . Studies on the epidemiology of nontuberculous mycobacteriosis in Japan. Am Rev Respir Dis. 1988; 137(6):1280-4. DOI: 10.1164/ajrccm/137.6.1280. View

16.

Santa Cruz D, Strayer D . The histologic spectrum of the cutaneous mycobacterioses. Hum Pathol. 1982; 13(5):485-95. DOI: 10.1016/s0046-8177(82)80032-4. View

17.

Blanchard D, Pearson C, Freitag C, Djeu J . Mycobacterium avium-intracellulare induces interleukin-6 from human monocytes and large granular lymphocytes. Blood. 1991; 77(10):2218-24. View

18.

Havlik Jr J, Horsburgh Jr C, Metchock B, Williams P, Fann S, Thompson 3rd S . Disseminated Mycobacterium avium complex infection: clinical identification and epidemiologic trends. J Infect Dis. 1992; 165(3):577-80. DOI: 10.1093/infdis/165.3.577. View

19.

Hirano T, Taga T, Nakano N, Yasukawa K, Kashiwamura S, Shimizu K . Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci U S A. 1985; 82(16):5490-4. PMC: 391148. DOI: 10.1073/pnas.82.16.5490. View

20.

Levine B, Chaisson R . Mycobacterium kansasii: a cause of treatable pulmonary disease associated with advanced human immunodeficiency virus (HIV) infection. Ann Intern Med. 1991; 114(10):861-8. DOI: 10.7326/0003-4819-114-10-861. View