5-Hydroxytryptamine (5-HT) and the Initiation of Migraine: New Perspectives

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1994 Sep 1

PMID 7824037

Citations 17

Authors

J R Fozard

H O Kalkman

Affiliations

Soon will be listed here.

Abstract

The hypothesis that 5-hydroxytryptamine (5-HT) acting through 5-HT2C receptors is a key factor in the initiation of migraine has been re-evaluated in the light of recent basic and clinical scientific developments. The key findings are that nitric oxide is an important trigger for migraine, that 5-HT2B/5-HT2C receptors are present on endothelial cells and trigger nitric oxide release when activated and that supersensitivity of the 5-HT2B/5-HT2C receptor is a neurochemical feature predisposing to headache. Taken together the data bring new perspectives to the role of 5-HT acting through 5-HT2C (or closely similar) receptors in the initiation of migraine.

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