The Iron-responsive Element Binding Protein: a Target for Synaptic Actions of Nitric Oxide

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1994 Dec 20

PMID 7809162

Citations 13

Authors

S R Jaffrey

N A Cohen

T A Rouault

R D Klausner

S H Snyder

Affiliations

Soon will be listed here.

Abstract

Molecular targets for the actions of nitric oxide (NO) have only been partially clarified. The dynamic properties of the iron-sulfur (Fe-S) cluster of the iron responsive-element binding protein (IRE-BP) suggested that it might serve as a target for NO produced in response to glutamatergic stimulation in neurons. In the present study, we demonstrate that N-methyl-D-aspartate, acting through NO, stimulates the RNA-binding function of the IRE-BP in brain slices while diminishing its aconitase activity. In addition, we demonstrate a selective localization of the IRE-BP in discrete neuronal structures, suggesting a potential role for this protein in the response of neurons to NO.

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