Gastric Acid Secretion

Overview

Journal Am J Dig Dis

Specialty Gastroenterology

Date 1976 May 1

PMID 779460

Authors

L F Wright

B I Hirschowitz

Affiliations

Soon will be listed here.

Abstract

Advances in the understanding of physiologic control of gastric secretion raise the hope that an effective nonsurgical therapy for peptic ulcer disease will be developed soon. This paper reviews these advances with special emphasis upon those aspects of hormonal control, cyclic nucleotide function, and histamine activity which may have therapeutic applications.

References

GROSSMAN M, Konturek S . Inhibition of acid secretion in dog by metiamide, a histamine antagonist acting on H2 receptors. Gastroenterology. 1974; 66(4):517-21. View

COHEN M, Debas H, HOLUBITSKY I, Harrison R . Caffeine and pentagastrin stimulation of human gastric secretion. Gastroenterology. 1971; 61(4):440-4. View

Dousa T, Code C . Effect of histamine and its methyl derivatives on cyclic AMP metabolism in gastric mucosa and its blockade by an H2 receptor antagonist. J Clin Invest. 1974; 53(1):334-7. PMC: 301469. DOI: 10.1172/JCI107555. View

REHM W . Some aspects of the problem of gastric hydrochloric acid secretion. Arch Intern Med. 1972; 129(2):270-8. View

Eichhorn J, Salzman E, Silen W . Cyclic GMP response in vivo to cholinergic stimulation of gastric mucosa. Nature. 1974; 248(445):238-9. DOI: 10.1038/248238a0. View

Johnson L, Chandler A . RNA and DNA of gastric and duodenal mucosa in antrectomized and gastrin-treated rats. Am J Physiol. 1973; 224(4):937-40. DOI: 10.1152/ajplegacy.1973.224.4.937. View

Schwartz M, KASHIWA H, Jacobson A, REHM W . Concentration and localization of calcium in frog gastric mucosa. Am J Physiol. 1967; 212(2):241-6. DOI: 10.1152/ajplegacy.1967.212.2.241. View

UVNAS B, EMAS S, Fyro B, Sjodin L . The interaction between vagal impulses and gastrin in the control of gastric acid secretion. Am J Dig Dis. 1966; 11(2):103-12. DOI: 10.1007/BF02239235. View

Davison J, Fahrner P, Schofield B, Tepperman B . The role of the intramural cholinergic innervation in the acid response of the parietal cell to gastrin derivatives. Can J Physiol Pharmacol. 1974; 52(3):469-82. DOI: 10.1139/y74-063. View

10.

Johnson L, GROSSMAN M . Secretin: the enterogastrone released by acid in the duodenum. Am J Physiol. 1968; 215(4):885-8. DOI: 10.1152/ajplegacy.1968.215.4.885. View

11.

GREGORY R, TRACY H . The preparation and properties of gastrin. J Physiol. 1961; 156:523-43. PMC: 1359901. DOI: 10.1113/jphysiol.1961.sp006691. View

12.

Nylander B, Andersson S . Gastric secretory inhibition induced by three methyl analogs of prostaglandin E2 administered intragastrically to man. Scand J Gastroenterol. 1974; 9(8):751-8. View

13.

Hirschowitz B, Sachs G . Vagal gastric secretory stimulation by 2-deoxy-D-glucose. Am J Physiol. 1965; 209(3):452-60. DOI: 10.1152/ajplegacy.1965.209.3.452. View

14.

Reed J, Sanders D, Thorpe V . The effect of splanchnic nerve stimulation on gastric acid secretion and mucosal blood flow in the anaesthetized cat. J Physiol. 1971; 214(1):1-13. PMC: 1331818. DOI: 10.1113/jphysiol.1971.sp009415. View

15.

Mainardi M, Maxwell V, Sturdevant R, Isenberg J . Metiamide, an H2-receptor blocker, as inhibitor of basal and meal-stimulated gastric acid secretion in patients with duodenal ulcer. N Engl J Med. 1974; 291(8):373-6. DOI: 10.1056/NEJM197408222910801. View

16.

Sachs G, Collier R, Shoemaker R, Hirschowitz B . The energy source for gastric H+ secretion. Biochim Biophys Acta. 1968; 162(2):210-9. DOI: 10.1016/0005-2728(68)90103-5. View

17.

Stadil F, Rehfeld J . Gastrin response to insulin after selective, highly selective, and truncal vagotomy. Gastroenterology. 1974; 66(1):7-15. View

18.

Mao C, Jacobson E, Shanbour L . Mucosal cyclic AMP and secretion in the dog stomach. Am J Physiol. 1973; 225(4):893-6. DOI: 10.1152/ajplegacy.1973.225.4.893. View

19.

Kimbert D . Cyclic nucleotides and their role in gastrointestinal secretion. Gastroenterology. 1974; 67(5):1023-64. View

20.

Nakamura M, Nakajima S, Magee D . Action of pancreozymin preparations on gastric acid secretion. Gut. 1968; 9(4):405-10. PMC: 1552733. DOI: 10.1136/gut.9.4.405. View