Noninvasive Diagnosis of Mesenteric Ischemia Using a SQUID Magnetometer

Overview

Journal Ann Surg

Specialty General Surgery

Date 1995 Jun 1

PMID 7794074

Citations 20

Authors

W O Richards

C L Garrard

S H Allos

L A Bradshaw

D J Staton

J P Wikswo Jr

Affiliations

Soon will be listed here.

Abstract

Objective: The authors assessed the ability of a Superconducting Quantum Interference Device (SQUID) magnetometer to noninvasively detect mesenteric ischemia in a rabbit model.

Summary Background Data: Superconducting Quantum Interference Device magnetometers have been used to detect magnetic fields created by the basic electrical rhythm (BER) and to detect changes in BER of exteriorized bowel of anesthetized rabbits during mesenteric ischemia.

Methods: The BER of rabbit ileum was noninvasively measured transabdominally using a SQUID magnetometer and compared with the electrical activity recorded with surgically implanted serosal electrodes before, during, and after snare occlusion of the superior mesenteric artery.

Results: Transabdominal SQUID recording of BER frequency was highly correlated to the measurements obtained with electrodes (R = 0.91). Basic electrical rhythm frequency decreased from 16.4 +/- 0.8 to 8.3 +/- 0.3 cpm (p < 0.001) after 25 minutes of ischemia. Reperfusion of ischemic bowel resulted in recovery of BER frequency to 14.3 +/- 0.4 cpm 10 minutes after blood flow was restored.

Conclusions: A SQUID magnetometer is capable of noninvasively detecting mesenteric ischemia reliably and at an early stage by detecting a significant drop in BER frequency. These positive findings have encouraged the authors to continue development of clinically useful, noninvasive, detection of intestinal magnetic fields using SQUID magnetometers.

Citing Articles

Electromechanical Response of Mesenteric Ischemia Defined Through Simultaneous High-Resolution Bioelectrical and Video Mapping.

Kuruppu S, Cheng L, Angeli-Gordon T, Avci R, Paskaranandavadivel N Ann Biomed Eng. 2023; 52(3):588-599.

PMID: 37962674 DOI: 10.1007/s10439-023-03404-w.

Magnetoenterography for the Detection of Partial Mesenteric Ischemia.

Somarajan S, Muszynski N, Olson J, Bradshaw L, Richards W J Surg Res. 2019; 239:31-37.

PMID: 30782544 PMC: 6506857. DOI: 10.1016/j.jss.2019.01.034.

The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications.

Du P, Paskaranandavadivel N, Angeli T, Cheng L, OGrady G Wiley Interdiscip Rev Syst Biol Med. 2015; 8(1):69-85.

PMID: 26562482 PMC: 5097873. DOI: 10.1002/wsbm.1324.

Noninvasive biomagnetic detection of intestinal slow wave dysrhythmias in chronic mesenteric ischemia.

Somarajan S, Muszynski N, Cheng L, Bradshaw L, Naslund T, Richards W Am J Physiol Gastrointest Liver Physiol. 2015; 309(1):G52-8.

PMID: 25930082 PMC: 4491509. DOI: 10.1152/ajpgi.00466.2014.

Automated algorithm for GI spike burst detection and demonstration of efficacy in ischemic small intestine.

Erickson J, Velasco-Castedo R, Obioha C, Cheng L, Angeli T, OGrady G Ann Biomed Eng. 2013; 41(10):2215-28.

PMID: 23612912 PMC: 3863806. DOI: 10.1007/s10439-013-0812-8.

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